Month: November 2022

Taylor, Edward C.; Jacobi, Peter A. published an article in 1976, the title of the article was Pteridines. XXXVII. A total synthesis of L-erythro-biopterin and some related 6-(polyhydroxyalkyl)pterins.Product Details of 5098-14-6 And the article contains the following content:

6-(1-Erythro-1′,2′-dihydroxypropyl)pterin was prepared by cupric acetate oxidation of 5-deoxy-L-arabinose to its osone, transoximation with acetone oxime to the α-ketoaldoxime, condensation with benzyl α-aminocyanoacetate methanesulfate to give II, cyclization with guanidine to biopterin 8-oxide, and deoxygenation with sodium dithionite. The overall yield was 12%. In analogous fashion, 6-(D-arabino-tetrahydroxybutyl)pterin and 6-D-threo-trihydroxypropyl)pterin were prepared from D-glucose and D-xylose, resp. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Product Details of 5098-14-6

The Article related to biopterin synthesis, pterin hydroxyalkyl, arabinose oxidation condensation, neopterin, Carbohydrates: Monosaccharides, Glycals and other aspects.Product Details of 5098-14-6

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Barnathan, Gilles; Huynh Dinh Tam; Kolb, Annie; Igolen, Jean published an article in 1976, the title of the article was Synthesis of C-nucleosides. XI. 2-D-Arabinofuranosylimidazoles and 8-D-arabinofuranosylpurines.Electric Literature of 5098-14-6 And the article contains the following content:

The nucleoside analogs I (R = NH2, SH, R1 = H) were prepared by treating II (R1 = R2 = Bz, R3 = Cl, Br) with Hg(CN)2, cleaving benzoyl groups from II (R1 = R2 = Bz, R3 = CN), treating II (R1 = Bz, R2 = H, R3 = CN) with PhCH2SH, cyclizing II (R1 = Bz, R2 = H, R3 = CH(:NH)SCH2Ph) with H2NCH(CN)2, cyclizing II (R1 = Bz, R2 =H, R3 = 4-cyano-5-amino-2-imidazolyl) with HC(:NH)NH2 or HC(OEt)3 and NaSH, and cleaving the benzoyl groups from I (R1 = Bz). The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Electric Literature of 5098-14-6

The Article related to adenine arabinofuranosyl, mercaptopurine arabinofuranosyl, arabinofuranosyl adenine mercaptopurine, imidazole arabinofuranosyl, Carbohydrates: Nucleosides, Nucleotides and other aspects.Electric Literature of 5098-14-6

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Tam Huynh Dinh; Kolb, Annie; Gouyette, Catherine; Igolen, Jean published an article in 1975, the title of the article was Synthesis of C-nucleosides. VII. β-D-Ribofuranosyl-2- and -8-adenines.Application In Synthesis of 2-Aminomalononitrile 4-methylbenzenesulfonate And the article contains the following content:

Benzyl (O-benzoyl-5-D-ribofuranosyl)thioformimidate reacted with aminomalodinitrile or with 5-amino-4-cyanoimidazole to yield the two C-nucleoside analogs I and II of adenosine. The β-configuration was determined with NMR and CD spectra. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Application In Synthesis of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to ribosylthioformimidate aminomalonitrile cycloaddition, imidazole amino ribosylthioformimidate cycloaddition, adenosine carbon nucleoside, Carbohydrates: Nucleosides, Nucleotides and other aspects.Application In Synthesis of 2-Aminomalononitrile 4-methylbenzenesulfonate

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On December 14, 2006, Meyer, Adam Gerhard; Winzenberg, Kevin Norman; Sawutz, David G.; Riches, Andrew Geoffrey published a patent.Product Details of 34662-29-8 The title of the patent was Preparation of N-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and N-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives as ecto- and endoparasiticides. And the patent contained the following:

The title derivatives I, II and III [R = H, alkyl, alkenyl, alkynyl, aralkyl;, etc.; R1-9 = H, CN, NO2, halo, etc.; X = O, S, SO, etc.] are prepared as ecto- and endoparasiticides. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Product Details of 34662-29-8

The Article related to phenyltrifluoromethanesulfonamide derivative preparation endoparasiticide ectoparasiticide, Agrochemical Bioregulators: Invertebrate and other aspects.Product Details of 34662-29-8

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Dawood, Dina H.; Srour, Aladdin M.; Saleh, Dalia O.; Huff, Kelley J.; Greco, Francesca; Osborn, Helen M. I. published an article in 2021, the title of the article was New pyridine and chromene scaffolds as potent vasorelaxant and anticancer agents.Formula: C12H7N3 And the article contains the following content:

Based on studies that have reported the association between cancer and cardiovascular diseases, new series of pyridine- (3a-o) and/or chromene- (4a-e) carbonitrile analogus were designed, synthesized and screened for their vasodilation and cytotoxic properties. The majority of the new chem. entities demonstrated significant vasodilation efficacies, compounds 3a, 3h, 3j, 3m, 3o, 4d and 4e exhibited the most promising potency with IC50 = 437.9, 481.0, 484.5, 444.8, 312.1, 427.6 and 417.2 μM, resp., exceeding prazosin hydrochloride (IC50 = 487.3 μM). Compounds 3b-e, 3k and 3l also, revealed moderate vasodilation activity with IC50 values ranging from 489.7 to 584.5 μM. In addition, the anti-proliferative activity evaluation of the exptl. compounds at 10 μM on the MCF-7 and MDA-MB 231 breast cancer cell lines illustrated the excellent anti-proliferative properties of derivatives 3d, 3g and 3i. Compound 3d was the most potent analog with IC50 = 4.55 ±0.88 and 9.87 ±0.89 μM against MCF-7 and MDA-MB 231, resp. Moreover, compound 3d stimulated apoptosis and cell cycle arrest at the S phase in MCF-7 cells in addition to its capability in accumulation of cells in pre-G1 phase and activating caspase-3. Furthermore, the mol. docking of 3d was performed to discover the binding modes within the active site of caspase-3. 3d, as the only common bi-functional agent among the tested hits, demonstrated that new pyridine-3-carbonitrile derivatives bearing cycloheptyl ring systems offer potential as new therapeutic candidates with combined vasodilation and anticancer properties. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Formula: C12H7N3

The Article related to pyridine chromene scaffold vasorelaxant anticancer agent, Placeholder for records without volume info and other aspects.Formula: C12H7N3

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On November 1, 2022, Ozbek, Begum Berna; Aktan, Ebru; Seferoglu, Zeynel published an article.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Novel push-pull organic dyes bearing Indan-2-one/Inden-1-ylidene and coumarin: Synthesis and photophysical properties. And the article contained the following:

Two novel coumarin-indanone-based probes were designed, synthesized, and characterized by 1H NMR, 13C NMR, FT-IR, and LC-MS spectroscopy methods. One of these Michael addition type probes displays selectivity and sensitivity for the cyanide anion over the other anions. These dye showed rapid fluorescence and colorimetric responses and excellent selectivity for cyanide anion during the detection process within DMSO and in DMSO/H2O (9:1, volume/volume). By adding cyanide anion to the structure by the Michael mechanism, the double bond was broken and the electron transfer was stopped, thus the intramol. charge transfer (ICT) was blocked by leaving the electron-withdrawing group out of conjugation. As a result, the hypsochromic shift was observed in absorbance and fluorescence spectra. The other dye showed selectivity but was not specific. In addition, the structural properties, frontier MOs, absorption spectra, cyanide addition mechanism, and MEP surface maps of the probes were obtained theor. by using the DFT method. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to coumarin organic dye bearing novel push pull photophys property, Placeholder for records without volume info and other aspects.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

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On July 1, 2021, Yahya, Mohamed; Cakmaz, Deniz; Achelle, Sylvain; le Gall, Estelle; Sahin, Ertan; Seferoglu, Zeynel published an article.Recommanded Product: 2510-01-2 The title of the article was Synthesis, photophysical, thermal properties and X-Ray studies of novel organic dyes bearing Inden-1-ylidene and fluorene. And the article contained the following:

Organic conjugated compounds containing various substituents 3-amino-2,4-dicyano-1-aryl-9H-fluorene and 1-dicyanomethylene-2-aryl-indone derivatives were successfully obtained. Various routes and synthesis methods, such as one-pot, multi-step, and microwave irradiation (MWI), were explored for efficiency. Spectroscopic methods were used to characterize of the synthesized compounds Furthermore (E)-2-(2-(anthracen-9-ylmethylene)-2,3-dihydro-1H-inden-1-ylidene) malononitrile (2b) compound which exhibited a crystal structure was also characterized via X-ray technique. The thermogravimetric anal. (TGA) was used to investigate the thermal stability. Finally, the photophys. properties of the synthesized compounds were also investigated using UV-vis and fluorescence. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2510-01-2

The Article related to indenylidene fluorene organic dye photophys thermal x ray property, Placeholder for records without volume info and other aspects.Recommanded Product: 2510-01-2

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Cox, Oakley B.; Krojer, Tobias; Collins, Patrick; Monteiro, Octovia; Talon, Romain; Bradley, Anthony; Fedorov, Oleg; Amin, Jahangir; Marsden, Brian D.; Spencer, John; von Delft, Frank; Brennan, Paul E. published an article in 2016, the title of the article was A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate And the article contains the following content:

Research into the chem. biol. of bromodomains has been driven by the development of acetyl-lysine mimetics. The ligands are typically anchored by binding to a highly conserved asparagine residue. Atypical bromodomains, for which the asparagine is mutated, have thus far proven elusive targets, including PHIP(2) whose parent protein, PHIP, has been linked to disease progression in diabetes and cancers. The PHIP(2) binding site contains a threonine in place of asparagine, and solution screening have yielded no convincing hits. We have overcome this hurdle by combining the sensitivity of X-ray crystallog., used as the primary fragment screen, with a strategy for rapid follow-up synthesis using a chem.-poised fragment library, which allows hits to be readily modified by parallel chem. both peripherally and in the core. Our approach yielded the first reported hit compounds of PHIP(2) with measurable IC50 values by an AlphaScreen competition assay. The follow-up libraries of four poised fragment hits improved potency into the sub-mM range while showing good ligand efficiency and detailed structural data. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to poised fragment library phip inhibitor bromodomain crystal structure, Placeholder for records without volume info and other aspects.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

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On February 15, 2022, Paul, Priya Kumari; Mehta, Raj Kumar; Yadav, Mahendra; Obot, I. B. published an article.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Theoretical, electrochemical and computational inspection for anti-corrosion activity of triazepine derivatives on mild steel in HCl medium. And the article contained the following:

The two triazepine derivatives, 2-amino-9-(1H-indol-3-yl)-4-(4-methoxyphenyl)-7-oxo-1,7-dihydropyrido[1,2-b][1,2,4]triazepine-3,8,10-tricarbonitrile [AITT] and Et 2-amino-8,10-dicyano-9-(2-hydroxy-3-methoxyphenyl)-4-(4-methoxyphenyl)-7-oxo-1,7-dihydropyrido [1,2 -b][1,2,4]triazepine-3-carboxylate [EHTC] were successfully synthesized and demonstrated as corrosion inhibitor for mild steel in 15% HCl medium. Their auspicious inhibiting performance was measured by weight loss measurement and the electrochem. impedance spectroscopic method. The adsorption of inhibitors chem. or phys. on the exposed metal surface is the main key factor behind the protection mechanism. The investigation at an optimum concentration of 200 ppm (303 K) showed the inhibitor AITT and EHTC with 96.88% and 95.56% inhibition efficiency. The functional groups attached to inhibitor AITT encourages the electron d. over the whole mol. and makes it more efficient as a corrosion inhibitor than EHTC. The minimization of cathodic as well as anodic reactions from the potentiodynamic polarization method reveals the inhibitors as mixed-type inhibitors which is also supported by the computed free energy of adsorption values from best fitted Langmuir Adsorption isotherm. The extreme improvement in damaged surface (inhibitor-free medium) was found on the application of inhibitors which is characterized by the surface topog. analyses FESEM and AFM. The elemental anal. of the inhibited metal surface was executed by XPS anal. The computational methods as Monte-Carlo Simulation, DFT and Fukui calculations, were also employed for the justification of outcomes from exptl. methods. All the observations were mutually supported. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to triazepine derivative synthesis mild steel anti corrosion evaluation, Placeholder for records without volume info and other aspects.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

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Bizzarri, Bruno Mattia; Fanelli, Angelica; Botta, Lorenzo; De Angelis, Marta; Palamara, Anna Teresa; Nencioni, Lucia; Saladino, Raffaele published an article in 2021, the title of the article was Aminomalononitrile inspired prebiotic chemistry as a novel multicomponent tool for the synthesis of imidazole and purine derivatives with anti-influenza A virus activity.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate And the article contains the following content:

Amino imidazole carbonitrile derivatives decorated with α-amino acid side-chains have been synthesized by a multicomponent microwave assisted reaction inspired by the prebiotic chem. of aminomalononitrile as a tool for generating high chem. diversity. These compounds were used as annulation synthons for the preparation of 8,9-disubstituted-6,9-dihydro-1H-purin-6-ones by reaction with formic acid as a simple C-1 donor reagent. The novel heterocycles were characterized by significant activity against influenza A virus, amino imidazole carbonitrile derivatives showing the highest activity. Thus, the chem. complexity generated by prebiotic chem. furnished a general tool for the identification of novel antiviral agents. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to imidazole purine derivative aminomalononitrile prebiotic chem antiinfluenza virus activity, Placeholder for records without volume info and other aspects.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

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