Month: November 2022

Poomathi, Nataraj; Perumal, Paramasivan T. published an article in 2016, the title of the article was Cinchona alkaloid and di-tert-butyl dicarbonate-DMAP promoted efficient synthesis of (E)-nitroolefins.Formula: C12H7N3 And the article contains the following content:

Herein, an alternative metal-free protocol for the synthesis of β-nitroolefins from arylidene malononitriles using cinchona alkaloid along with di-tert-Bu dicarbonate-DMAP in high yields with total selectivity is reported. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Formula: C12H7N3

The Article related to nitroolefin preparation cinchona alkaloid catalyst dmap tert butyl dicarbonate, General Organic Chemistry: Synthetic Methods and other aspects.Formula: C12H7N3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Saidalimu, Ibrayim; Guo, Ming; Tokunaga, Etsuko; Shibata, Norio published an article in 2016, the title of the article was Direct Fluoro-aminosulfenylation of Active Methylenes by Dialkylaminosulfur Trifluorides under Catalyst-Free Conditions.SDS of cas: 2510-01-2 And the article contains the following content:

The direct fluoro-aminosulfenylation of active methylene compounds, e.g., 2-(2,3-dihydro-1H-inden-1-ylidene)malononitrile by diethylaminosulfur trifluoride and its derivatives F3SR (R = dimethylamino, diethylamino, bis(2-methoxyethyl)amino, morpholino) has been disclosed. A variety of α-fluorinated α-sulfenamides with a tetrasubstituted carbon center, e.g., I were synthesized from active methylene compounds under mild reaction conditions. This direct fluoro-aminosulfenylation reaction occurs very smoothly under metal-free and base-free conditions. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).SDS of cas: 2510-01-2

The Article related to sulfenamide fluoro preparation, active methylene compound dialkylaminosulfur trifluoride fluoro aminosulfenylation, General Organic Chemistry: Synthetic Methods and other aspects.SDS of cas: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chowhan, Bushra; Gupta, Monika; Sharma, Neha published an article in 2019, the title of the article was Designing of Ultrafine PdNPs Immobilized Pyridinic-N Doped Carbon and Evaluation of its Catalytic Potential for Konevenagel Condensation, Synthesis of 4H-pyran Derivatives and Nitroreduction.Application In Synthesis of 2-((1H-Indol-3-yl)methylene)malononitrile And the article contains the following content:

The desiging of ultrafine Pd-based nanocatalyst containing N-doped carbon structure (Pd@NC) was reported. The material was prepared by direct dehydration at 120 °C followed by mixing and heating with a dopant (ammonium oxalate) at 150 °C in a furnace. The Pd@NC nanocatalyst containing electron-rich pyridinic-N doped carbon structure, was thoroughly characterized by various techniques namely SEM, EDX, TEM, FTIR, ICP-AES, XRD, XPS, TGA and Raman spectroscopy. The utility of the Pd@NC nanocatalyst was explored for base-free Knoevenagel condensation and 4H-pyran derivatives and also in the reduction of nitroarenes under mild and greener conditions. Further, the optical property was explored using photoluminescence spectroscopy and band gap was also calculated The heterogeneous nature and stability of the catalyst facilitated by its ease of separation for long-term performance and recycling studies showed that catalyst was robust and remained active upto six recycling experiments Also, the leaching of metal was confirmed by ICP-AES. The superiority of the catalyst was attributed to the metal support interaction (MSI) between metallic palladium and pyridinic-N doped carbon to acquire excellent catalytic activity and changing the reducing nature of NaBH4 towards nitro functionality. The MSI between pyridinic-N dopant on the carbon structure and PdNPs produces highly active sites for catalytic performance under mild conditions. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Application In Synthesis of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to palladium nanoparticle preparation thermal stability, arylidene malononitile preparation, pyran preparation, aniline preparation green chem, General Organic Chemistry: Synthetic Methods and other aspects.Application In Synthesis of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On March 15, 2021, Azad, Iqbal; Khan, Tahmeena; Ahmad, Rumana; Kamal, Azhar; Khan, Abdul Rahman; Nasibullah, Malik published an article.Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was A Simplistic Approach for Preparation of Alkylidenemalononitrile Derivatives: Characterization, In silico Studies, Quantum Chemical Evaluation, Molecular Docking, and In vitro Biological Activity Evaluation. And the article contained the following:

A new and efficient green grinding-based catalyst free Knoevenagel condensation of aldehydes/ketones and malononitrile for the rapid preparation of twelve malononitrile I [R1 = H, Cl; R2= H, Cl ] and II [R3 = H, Br; R4 = H, Me, Ph ]was proposed. Characterization of the derivatives was done by 1H NMR, 13C NMR, IR, elemental and mass spectral analyses. Quantum chem. calculations were performed by DFT/B3LYP/6-31G(d,p) method. The exptl. and theor. spectra were found to be in good agreement with each other. Natural bond order (NBO) calculations were also performed to calculate the natural at. charges at at. sites. The present study also involved study of the intramol. charge transfer (ICT) interactions and the non-linear optical (NLO) properties. Critical drug character assessment parameters like metabolic transformation, druglikeness, ADMET (absorption, distribution, metabolism and excretion) and toxicol. analyses of the synthesized malononitrile derivatives were also performed. Mol. docking studies were performed against two target proteins viz. tyrosine-protein kinase (HCK) and ribonucleoside diphosphate reductase (RR). The synthesized malononitrile derivatives were also evaluated for their anticancer activity against the triple neg. breast cancer (TNBC) cell line (MDA-MB-231) while their antibacterial potential was tested against S. aureus and E. coli. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to alkylidenemalononitrile preparation antibacterial antitumor agent enzyme inhibitor mol docking, sar homo lumo stabilization energy mol structure green chem, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dewanji, Abhishek; van Dalsen, Leendert; Rossi-Ashton, James A.; Gasson, Eloise; Crisenza, Giacomo E. M.; Procter, David J. published an article in 2021, the title of the article was A general arene C-H functionalization strategy via electron donor-acceptor complex photoactivation.Formula: C10H7NO2 And the article contains the following content:

The photoactivation of electron donor-acceptor (EDA) complexes has emerged as a sustainable, selective and versatile strategy for the generation of radical species. However, when it comes to aryl radical formation, this strategy remains hamstrung by the electronic properties of the aromatic radical precursors and electron-deficient aryl halide acceptors are required. This has prevented the implementation of a general synthetic platform for aryl radical formation. Our study introduces triarylsulfonium salts as acceptors in photoactive EDA-complexes, used in combination with catalytic amounts of newly-designed amine donors. The sulfonium salt label renders inconsequential the electronic features of the aryl radical precursor and, more importantly, it is installed regioselectively in native aromatic compounds by C-H sulfenylation. Using this general, site-selective aromatic C-H functionalization approach, we have developed metal free protocols for the alkylation and cyanation of arenes, and showcased their application in both the synthesis and the late-stage modification of pharmaceuticals and agrochems. The experimental process involved the reaction of 4-Oxochroman-6-carbonitrile(cas: 138801-92-0).Formula: C10H7NO2

The Article related to arene carbon hydrogen functionalization donor acceptor complex photoactivation, alkylation cyanation triarylsulfonium salt silane intermediate radical mechanism, General Organic Chemistry: Synthetic Methods and other aspects.Formula: C10H7NO2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On May 31, 2017, Deilami, K.; Sayyahi, S. published an article.Name: 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Porous hierarchical magnesium oxide-based heterogeneous catalyst for the Knoevenagel condensation. And the article contained the following:

Herein, an operationally facile and efficient Knoevenagel reaction catalyzed by porous hierarchical MgO/Mg(OH)2 is presented. Condensation of various aldehydes with malononitrile proceeds under mild conditions and gives the target products with high yields. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Name: 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to porous hierarchical magnesium oxide catalyst preparation knoevenagel condensation, aryl aldehyde knoevenagel condensation malononitrile magnesium oxide catalyzed, General Organic Chemistry: Synthetic Methods and other aspects.Name: 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 2, 2006, Nishiyabu, Ryuhei; Anzenbacher, Pavel Jr. published an article.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was 1,3-Indane-Based Chromogenic Calixpyrroles with Push-Pull Chromophores: Synthesis and Anion Sensing. And the article contained the following:

Knoevenagel condensation of 2-formyl-octamethylcalix[4]pyrrole with selected 1,3-indanedione derivatives yields calix[4]pyrrole anion sensors with push-pull chromophores displaying strong intramol. charge transfer. The push-pull feature results in augmented signal output as well as in dramatic changes in anion selectivity exemplified by a 50-fold increase in acetate vs. chloride selectivity compared to the parent calix[4]pyrrole. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to indane chromogenic calixpyrrole push pull chromophore anion sensing, Inorganic Analytical Chemistry: Determinations and other aspects.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lv, Yongjun; Guo, Yong; Xu, Jian; Shao, Shijun published an article in 2011, the title of the article was Simple indole-based colorimetric sensors with electron-withdrawing chromophores: Tuning selectivity in anion sensing.Related Products of 75629-62-8 And the article contains the following content:

Three simple colorimetric anion sensors containing anthrone, 1,3-indanedione, and malononitrile as signaling chromophores and an indole binding site were designed and synthesized. The introduction of electron-withdrawing groups can not only provide chromogenic signal output, but also tune the sensitivity and selectivity of indole-based anion sensors by electron push-pull features. Their anion binding and sensing properties were studied in detail by dramatic color changes, UV-visible absorption, and 1H NMR. As results revealed, sensor I showed high selectivity for F- over AcO- and H2PO4- with a distinct change in color due to the deprotonation of indole NH group. The excellent selectivity of I for F- can be attributed to the fitness in the acidity of its NH-group, which is tuned to be able to distinguish the subtle difference in the affinity of F-, AcO-, and H2PO4- to NH proton. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Related Products of 75629-62-8

The Article related to indole based colorimetric sensor electron withdrawing chromophore, fluoride acetate dihydrogen phosphate sensing indole derivative colorimetric, Inorganic Analytical Chemistry: Determinations and other aspects.Related Products of 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 24, 2021, Cheng, Qiuli; Asha, Anika Benozir; Liu, Yang; Peng, Yi-Yang; Diaz-Dussan, Diana; Shi, Zuosen; Cui, Zhanchen; Narain, Ravin published an article.Product Details of 5098-14-6 The title of the article was Antifouling and Antibacterial Polymer-Coated Surfaces Based on the Combined Effect of Zwitterions and the Natural Borneol. And the article contained the following:

The development and application of natural antibacterial materials have always been the focus of biomedical research. Borneol as a natural antibacterial compound has received extensive attention. However, the hydrophobicity caused by its unique structure limits its application range to a certain extent. In this study, we combine zwitterionic 2-methacryloyloxyethyl phosphorylcholine (MPC) with a complex bicyclic monoterpene structure borneol compound and prepare an excellent antifouling and antibacterial surface via the Schiff-base bond. The prepared coating has excellent hydrophilicity verified by the contact angle (CA), and its polymer layer is confirmed by XPS. The zwitterion MPC and borneol moieties in the copolymer play a coordinating role, relying on super hydration and the special stereochem. structure to prevent protein adsorption and inhibit bacterial adhesion, resp., which are demonstrated by bovine serum albumin (BSA) adsorption and antibacterial activity test. Moreover, the water-soluble borneol derivative as the antibacterial surfaces we designed here was biocompatible toward MRC-5 (lung fibroblasts), as showed by in vitro cytotoxicity assays. Such results indicate the potential application of the as-prepared hydrophilic surfaces in the biomedical materials. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Product Details of 5098-14-6

The Article related to antifouling antibacterial polymer surface coating zwitterion borneol biocompatibility, antibacterial, antifouling, biocompatibility, hydrophilic, zwitterion, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.Product Details of 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 10, 2003, Moeller, Hinrich; Hoeffkes, Horst; Oberkobusch, Doris published a patent.SDS of cas: 2510-01-2 The title of the patent was Oxidative hair dyes containing aromatic compounds, other dyes and color intensifiers. And the patent contained the following:

The invention concerns oxidative hair dyes that contain aromatic compounds other dyes and color intensifiers. The components are selected from the group of primary and secondary aromatic amines, hydroxides, nitrogen-containing heterocycles, amino acids, oligopeptides, CH-acids and quaternary ammonium compounds Thus a dye contained(weight/weight%): Texapon NSO 18.00; Dehyton K 11.25; Hydrenol D 7.65; Lorol 1.80; Eumulgin 0.68; propylene carbonate 8.50; N-allylisatine 1.50; N,N-Bis(2’hydroxyethyl)-p-phenylene diamine sulfate 2.95; ascorbic acid 0.10; sodium sulfite 0.10; ammonia (25%) 4.00; water to 100; pH 9.20. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).SDS of cas: 2510-01-2

The Article related to oxidative hair dye aromatic, Essential Oils and Cosmetics: Hair Preparations and other aspects.SDS of cas: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts