Month: November 2022

Goud, S. Banuprakash; Guin, Soumitra; Prakash, Meher; Samanta, Sampak published an article in 2022, the title of the article was Cu(OAc)2/DABCO-mediated domino reaction of vinyl malononitriles with cyclic sulfamidate imines: access to 6-hydroxyaryl-2-aminonicotinonitriles.Category: nitriles-buliding-blocks And the article contains the following content:

A novel Cu(II)-salt/DABCO-mediated one-pot access to a myriad of highly substituted biol. relevant 2-aminonicotinonitriles possessing a resourceful phenolic moiety, e.g., I with satisfactory yields is reported. This method involves cyclic sulfamidate imines, e.g., benzo[e][1,2,3]oxathiazine 2,2-dioxide as 1C1N sources and different kinds of acyclic/cyclic vinyl malononitriles, e.g., 2-(1-phenylethylidene)malononitrile as 4C sources for pyridine synthesis via a vinylogous Mannich-cycloaromatization sequence process, creating two new C-N bonds under mild conditions. Importantly, this de novo strategy is applicable to gram-scale syntheses, underlining the method’s practicability and allowing for a wide range of substrates with excellent functional group tolerance. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Category: nitriles-buliding-blocks

The Article related to hydroxyaryl aminonicotinonitrile preparation, cyclic sulfamidate imine vinyl malononitrile domino vinylogous mannich cycloaromatization, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On July 30, 2019, Toh, Rou Jun; Evans, Richard; Thissen, Helmut; Voelcker, Nicolas H.; d’Ischia, Marco; Ball, Vincent published an article.Category: nitriles-buliding-blocks The title of the article was Deposition of Aminomalononitrile-Based Films: Kinetics, Chemistry, and Morphology. And the article contained the following:

In the last few years, the development of versatile coating chemistries has become a hot topic in surface science after the discovery that catecholamines can lead to conformal coatings upon oxidation from aqueous solutions Recently, it was found that aminomalononitrile (AMN), a mol. implicated in the appearance of life on earth, is an excellent prototype of novel material-independent surface functionalizing agents leading to conformal and biocompatible coatings in a simple and direct chem. process from aqueous solutions So far, very little insight has been gained regarding the mechanisms underlying coating deposition. In this paper, we show that the chem. evolution of AMN film deposition under slightly basic conditions is different in solution and on silica. Thereon, the coating proceeds via a nucleation process followed by further deposition of islands which evolve to produce nitrogen-rich superhydrophilic fibrillar structures. Addnl., we show that AMN-based material can form films at the air-solution interface from unshaken solutions These results open new vistas into the chem. of HCN-derived species of potential relevance in materials science. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Category: nitriles-buliding-blocks

The Article related to aminomalononitrile film surface structure, Surface Chemistry and Colloids: Solid-Liquid Systems and other aspects.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 30, 2001, Steiner, Thomas published an article.Related Products of 5098-14-6 The title of the article was The C-H…O hydrogen bond in (dicyanomethyl)ammonium p-toluenesulfonate. And the article contained the following:

In the title compound, C3H4N3+·C7H7O3S-, the activated C-H group of the cation forms a short but bent C-H…O H bond with a sulfonate O atom of the anion; C…O = 3.075(5) Å and C-H…O = 130°. Crystallog. data are given. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Related Products of 5098-14-6

The Article related to mol structure cyanomethylammonium toluenesulfonate, hydrogen bonding cyanomethylammonium toluenesulfonate, Crystallography and Liquid Crystals: Crystal Structure and other aspects.Related Products of 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 30, 2021, Nuellen, Max Peter; Schulze, Benjamin; Wudarczyk, Jakob Jacek published a patent.Related Products of 337965-61-4 The title of the patent was Organic compounds for use in organic electronic devices (OLED), semiconductor layer and display device. And the patent contained the following:

The present invention relates to a compound of formula I and an organic electronic device comprising a semiconductor layer which comprises a compound of formula I. The experimental process involved the reaction of 2-(6-Fluoropyridin-3-yl)acetonitrile(cas: 337965-61-4).Related Products of 337965-61-4

The Article related to organic compound electronic device oled semiconductor layer display device, Electric Phenomena: Semiconductor Junctions and Devices and other aspects.Related Products of 337965-61-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 22, 2017, Mobashery, Shahriar; Speri, Enrico; Chang, Mayland published a patent.Formula: C12H7N3 The title of the patent was Potentiators of beta-lactam antibiotics and combination therapy. And the patent contained the following:

Proteins of methicillin-resistant Staphylococcus aureus (MRSA), an antibiotic sensor/signal transducer, are phosphorylated on exposure to β-lactam antibiotics. This event is critical for the onset of the biochem. events that unleash induction of antibiotic resistance. The phosphorylation and the antibiotic-resistance phenotype can be abrogated in the presence of phenylpropanenitrile derivatives, eg. I, (X= O, CH2, S, SO2, or a direct bond; R1= CN, SO2Me, CONH2, CO2H, etc.; m= 1,2,3,4; n= 1,2,3,4,5; R2= H, halo, alkyl, alkoxy, heteroaryl, etc.; R3= halo, alkyl, alkoxy, heteroaryl, etc.), that restore susceptibility of the organism to β- lactam antibiotics. The invention thus provides compounds and methods for abrogating antibiotic resistance to β-lactam antibiotics and for treating infections causes by antibiotics prone to developing resistance by potentiating β-lactam antibiotics. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Formula: C12H7N3

The Article related to phenylpropanenitrile derivative betalactam antibiotic resistance mrsa, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Formula: C12H7N3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 1, 2018, Yalcin, Ergin; Matkovic, Marija; Jukic, Marijana; Obrovac, Ljubica Glavas; Piantanida, Ivo; Seferoglu, Zeynel published an article.Application of 2510-01-2 The title of the article was Novel fluorene/fluorenone DNA and RNA binders as efficient non-toxic ds-RNA selective fluorescent probes. And the article contained the following:

A series of structurally similar 1-substituted heteroaryl fluorene derivatives were prepared in a simple single step reaction, oxidized to fluorenones and then both, fluorenes and fluorenones, were methylated to enhance the solubility and increase the affinity to DNA/RNA. Interactions of both, fluorene and fluorenone analogs with various ds-DNA, ds-RNA revealed strong ds-DNA/RNA binding, and various thermal stabilization effects. Most intriguingly, some fluorene derivatives showed opposite fluorescence change (increase for ds-RNA and decrease for ds-DNA), which was not previously reported for any fluorene analog. CD experiments along with other methods support ds-DNA minor groove binding and major groove ds-RNA binding. All compounds showed negligible interaction with G-quadruplex DNA. Very low cell cytotoxicity of studied compounds combined with very efficient cellular uptake makes these fluorescent dyes safe for laboratory applications. Moreover, especially compounds which show opposite fluorescence response to ds-DNA and ds-RNA, are promising lead compounds for further studies aimed toward ds-RNA-specific fluorescence markers. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application of 2510-01-2

The Article related to fluorene fluorenone binding dsdna dsrna fluorescent probe, General Biochemistry: Nucleic Acids and Their Constituents and other aspects.Application of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 30, 2001, Mishriky, N.; Girgis, A. S.; Asaad, F. M.; Ibrahim, Y. A.; Sobieh, U. I.; Fawzy, N. G. published an article.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Simple synthesis of condensed pyran containing compounds and their antimicrobial properties. And the article contained the following:

Reaction of various fused pyran compounds with formic acid was studied. Thus, refluxing 6-aminopyrano[2,3-c]pyrazole-5-carbonitriles with formic acid afforded the corresponding 3-aryl-3-(5-hydroxy-3-methyl-1H-pyrazole-4-yl)propanoic acids. Reaction of formic acid with 2-amino-4H-1-benzopyran-3-carbonitriles gave quinoline-2,5(1H,6H)-diones. The study was also extended toward spiro compounds possessing pyran residue. The antimicrobial properties of the prepared compounds was screened. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to fused pyran preparation antimicrobial property, Heterocyclic Compounds (More Than One Hetero Atom): General and other aspects.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On May 31, 1997, Ram, Vishnu Ji; Nath, Mahendra published an article.SDS of cas: 75629-62-8 The title of the article was Synthesis of diheteroarylmethanes from activated nitriles. And the article contained the following:

Novel procedures for the preparation of diheteroarylmethanes, e.g., the pyrimidinylindolylmethanes I (R = H, benzyl; R1 = amino, Me, Ph, pyridyl, morpholino), were developed from the base-catalyzed condensation-cyclization of indolylmethylmalononitrile II (R = H, R1 = H, benzyl) with amidine, dicyandiamide, hydroxylamine, hydrazine, and thioglycolic acid. The acid catalyzed reaction of II (R2 = bond) with thiosemicarbazide affords thiadiazole III. Base-catalyzed reaction of 3-indolylacetonitrile with dicyandiamide gives sym. triazine IV. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).SDS of cas: 75629-62-8

The Article related to diheteroarylmethane preparation, methane diheteroaryl preparation, nitrile condensation cyclization, Heterocyclic Compounds (More Than One Hetero Atom): General and other aspects.SDS of cas: 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On October 31, 1980, Taylor, Edward C.; Sun, Jung Hui published an article.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was A new synthesis of aminomalononitrile tosylate. And the article contained the following:

The title salt (I) was prepared from NaCH(CN)2. Thus, 2,4,6-Me3C6H2SO2ONH2 was added to NaCH(CN)2 in THF, the mixture stirred under N2 2.5 h at 0°, the 2,4,6-Me3C6H2SO3Na formed was separated, 4-MeC6H4SO3H added, and the mixture refrigerated overnight to give I. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to aminomalononitrile tosylate, malononitrile amino tosylate, Aliphatic Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On August 31, 1988, Hiremath, Shivayogi P.; Ullagaddi, Ashok; Sekhar, K. Raja; Purohit, Muralidhar G. published an article.Application of 75629-62-8 The title of the article was Synthesis of various pyrazole-1-carbonylindoles. And the article contained the following:

2-Indolecarbohydrazides were treated with MeCOCH2CO2Et to give pyrazolinones I (R1 = H, Me; R2 = OMe, Me, Cl, Br H, OEt; R3 = H Me; R4 = Me, Ph, H). Pyrazoles II were prepared from hydrazides and MeCOCH2COMe. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Application of 75629-62-8

The Article related to pyrazole indolecarbonyl, indole pyrazolecarbonyl, indolecarbohydrazide cyclocondensation acetoacetate acetylacetone, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application of 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts