Month: November 2022

Koeckritz, Peter; Sattler, Ruth; Liebscher, Juergen published an article in 1985, the title of the article was Iminoformylation reaction of substituted crotononitriles. I. Synthesis of new N,N-disubstituted 4-amino-1,1-dicyanobuta-1,3-dienes.Product Details of 2510-01-2 And the article contains the following content:

Condensation of H2CRCR1:C(CN)2 [R = H, Me; R1 = e.g. Et, Ph, 2-thienyl; RR1 = e.g. (CH2)4] with R2R3NH [R2 = alkyl, Ph; R3 = R2, PhCH2, cyclohexyl; R2R3 = (CH2)4, (CH2)5, (CH2)2O(CH2)2] and (EtO)3CH in the presence of carboxylic acids as catalysts gave ∼70 title compounds R2R3NCH:CRCR1:C(CN)2 in moderate to good yields depending on steric conditions. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Product Details of 2510-01-2

The Article related to crotononitrile iminoformylation orthoformate amine, carboxylic acid iminoformylation catalyst, butadiene aminodicyano, Aliphatic Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Product Details of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bertini, Simone; Saccomanni, Giuseppe; DelCarlo, Sara; Digiacomo, Maria; Gargini, Claudia; Piano, Ilaria; Campisi, Giuseppe Matteo; Ghidoni, Riccardo; Macchia, Marco; Manera, Clementina published an article in 2017, the title of the article was Application of an improved HPLC-FL method to screen serine palmitoyl transferase inhibitors.Product Details of 34662-29-8 And the article contains the following content:

In this work, we reported the application and validation of an improved high-performance liquid chromatog. method coupled with a fluorimetric detector (HPLC-FL) to screen the activity of two heterocyclic derivatives reported as serine palmitoyl transferase (SPT) inhibitors. The anal. conditions were optimized in terms of the derivatization procedure, chromatog. condition, extraction procedure, and method validation according to EMEA guidelines. Once fully optimized, the method was applied to assess the SPT-inhibitory activity of the above-mentioned derivatives and of the reference inhibitor myriocin. The obtained results, expressed as a percentage of residual SPT activity, were compared to those obtained with the reference radio immune assay (RIA). The good correlation between the two types of assay demonstrated that the improved HPLC-FL method is suitable for a preliminary and rapid screening of potential SPT-inhibitors. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Product Details of 34662-29-8

The Article related to serine palmitoyl transferase inhibitor hplcfl method, hplc, spt, enzymatic assay, screening, serine palmitoyl transferase, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Product Details of 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Alizadeh, Abdolali; Hosseini, Seyed Yasub; Vahabi, Amir Hossein published an article in 2014, the title of the article was Substituent effects and structural features of α,α-dicyanoolefins and ketene dithioacetals on directing polyfunctionalized 2,6-dicyanoanilines or pyrazolo[1,5-a]pyridines.Recommanded Product: 2510-01-2 And the article contains the following content:

An efficient and facile synthesis of pyrazolo[1,5-a]pyridine derivatives, e.g., I, and polyfunctionalized 2,6-dicyanoaniline derivatives, e.g., II, via vinylogous Michael addition of cyclic or acyclic α,α-dicyanoolefins to electron-deficient ketene dithioacetals in the presence of hydrazine at room temperature was described. The prominent feature of this one-pot procedure is an apparent dichotomy in the nature of products, which was dictated by the structure and functionality of substrates. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2510-01-2

The Article related to pyrazolopyridine dicyanoaniline preparation substituent structure effect, dicyanoolefin ketene dithioacetal michael addition, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Recommanded Product: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On March 31, 2000, Abdelhamid, Abdou O.; Zohdi, Hussein F.; Ziada, Mahmoud M. published an article.Recommanded Product: 75629-62-8 The title of the article was A facile synthesis of [1,2,4]triazino[4,5-a]benzimidazoles, pyrazolo[5,1-c]triazines, triazolo[5,1-c]triazines and pyrido[1,2-a]benzimidazoles. And the article contained the following:

Triazino[4,5-a]benzimidazoles have been obtained by coupling of arenediazonium chlorides with Et (1-ethoxycarbonyl)benzimidazole-2-acetate. Pyrazolo[5,1-c]triazines and triazolo[5,1-c]triazines have been synthesized via coupling of diazotized heterocyclic amines with Et benzimidazole-2-acetate. Et benzimidazole-2-acetate reacts with 1,1-dicyano-2-substituted ethenes and 1-cyano-1-ethoxycarbonyl-2-substituted ethenes to give pyrido[1,2-a]benzimidazoles, resp. Structures of the newly synthesized compounds are confirmed on the basis of elemental analyses, spectral data and alternative methods whenever possible. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Recommanded Product: 75629-62-8

The Article related to triazinobenzimidazole preparation, pyrazolotriazine preparation, triazolotriazine preparation, pyridobenzimidazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Recommanded Product: 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Koeckritz, P.; Schmidt, L.; Liebscher, J. published an article in 1987, the title of the article was Iminoformylation reaction of substituted crotononitriles. II. The reaction of ylidenemalonitriles with formamide acetals in the presence of acetic acid.Formula: C12H8N2 And the article contains the following content:

Iminoformylation of ylidenemalononitrile with formamide acetals in the presence of AcOH gave good yields of 1,1-dicyano-4-aminobuta-1,3-dienes, building blocks to heterocycles. Thus, condensation of H2CRCR1:C(CN)2 (R = H, Me, Et, R1 = Me, Et, Me2CHCH2, Ph, PhCH:CH, etc.) with R2R3NCH(OMe)2 [R2,R3 = Me; R2R3 = CH2CH2OCH2CH2), (CH2)4] gave 34-99% R2R3NCH:CRCR1:C(CN)2. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Formula: C12H8N2

The Article related to crotononitrile iminoformylation, ylidenemalonitrile iminoformylation formamide acetal, cyanoaminobutadiene, butadiene cyano amino, Aliphatic Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Formula: C12H8N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Red’kin, R. G.; Shemchuk, L. A.; Chernikh, V. P.; Shishkin, O. V.; Shishkina, S. V. published an article in 2007, the title of the article was Synthesis of 4-(1H-indol-3-yl) derivatives of 2-amino-4H-pyran and 2-amino-4,6,7,8-tetrahydro-1H-quinolin-5-one.Recommanded Product: 75629-62-8 And the article contains the following content:

The novel heterocyclic compounds I (X = O, NR3; R1 = CN, CO2Et; R2 = H, Me; R3 = Ph, 4-MeC6H4, 4-HOC6H4, 4-MeOC6H4) were synthesized either by one-pot three-component condensation of 3-formylindole with active methylene compounds R1CH2CN and 1,3-diketone analogs, 3-HX-5,5-R22-substituted 2-cyclohexenones (II), or by two-step condensation of 3-formylindole with R1CH2CN followed by heterocyclization of the intermediate (indolyl)acrylonitriles with II. Acetylacetone, 4-hydroxycoumarin and 3-methyl-5-pyrazolone were also successfully used instead of II providing access to monocyclic and heterocycle-fused derivatives of I. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Recommanded Product: 75629-62-8

The Article related to quinolinone amino tetrahydro indolyl preparation, pyran amino indolyl preparation crystal structure, indole formyl condensation nitrile diketone, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Recommanded Product: 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Thanassi, John W. published an article in 1975, the title of the article was Reactions of aminomalononitrile with electrophiles.Related Products of 5098-14-6 And the article contains the following content:

Aminomalononitrile reacted with electrophiles, aldehydes and CH2:CHCN, under very mild conditions of temperature and pH to produce intermediates which, after acid hydrolysis, yielded amino acids, glycine, DL-erythro- and DL-threo-β-hydroxyaspartic acids, DL-glutamic acid, DL-threonine and allothreonine. The mechanism of their formation and the possible significance of these reactions in prebiotic syntheses are discussed. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Related Products of 5098-14-6

The Article related to aminomalononitrile electrophile reaction, aldehyde aminomalononitrile reaction, acrylonitrile aminomalononitrile reaction, amino acid biogenetic model, Synthesis of Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Related Products of 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 10, 2003, Moeller, Hinrich; Oberkobusch, Doris; Hoeffkes, Horst published a patent.Application of 2510-01-2 The title of the patent was Hair dyes containing acetal derivatives of pyridine and quinoline. And the patent contained the following:

The invention concerns hair dyes that contain dimethoxy-, diethoxy Me and Et derivatives of pyridine and quinoline for use without or with oxidation agents. Further included are components from the group of primary and secondary amines, hydroxy compounds, aryl amines, N-containing heteroaryls, amino acids, 2-9 amino acid-composed oligopeptides, or CH-acids. Thus 4-diethoxymethyl-1-methylquinolinium-p-toluene sulfate was synthesized and used as a 5 mmol ingredient with 5 mmol 3-amino-2-methylamino-6-methoxypyridine dihydrochloride in a hair dyeing experiment; intense greenish brown color was obtained. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application of 2510-01-2

The Article related to hair dye acetal pyridine quinoline oniumacetal, Essential Oils and Cosmetics: Packaging (Chemical Implication) and other aspects.Application of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 27, 2002, Li, Guiying; Peterson, John M.; Albaugh, Pamela; Currie, Kevin S.; Cai, Guolin; Gustavson, Linda M.; Lee, Kyungae; Hutchison, Alan; Singh, Vinod; Maynard, George D.; Yuan, Jun; Ling, Hong Xie; Ghosh, Manuka; Liu, Nian; Luke, George P.; Mitchell, Scott; Allen, Martin Patrick; Liras, Spiros published a patent.Reference of 3-Chloro-4-nitrobenzonitrile The title of the patent was Aryl or heteroaryl fused imidazoles as selective GABAA receptor ligands. And the patent contained the following:

Title compounds I [W = N or CR3, X = N or CR4, Y = N or CR5, Z = N or CR6 with the provision that no more than two of W, X, Y and Z are N; Q = O or CR7R8; R1 = H, haloalkyl, (un)substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, etc.; R2 = nitrogen containing 5-7 membered (un)substituted heteroaryl or heterocycloalkyl ring with up to 4 heteroatoms independently selected from N, S, and O; R3, R4, R5 and R6 are independently selected from H, halo, OH, NO2, CN, (un)substituted alkyl, alkoxy, etc.] and there pharmaceutically acceptable salts are prepared and disclosed as selective GABAA receptor ligands. Thus, II was prepared in five steps from malonyl dichloride and Et vinyl ether with imidazole ring formation via cyclocondensation of 3-amino-4-ethylaminobenzonitrile with 1-(3-fluorophenyl)-5-carboxymethylpyrazole. The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. Preferred compounds of the invention exhibit Ki values of < 100 nM for binding at the benzodiazepine site with more preferred compounds exhibiting Ki values of < 10 nM. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. This invention also relates to the use of I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Addnl. this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Reference of 3-Chloro-4-nitrobenzonitrile

The Article related to imidazole aryl preparation gaba receptor ligand cns agent, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Reference of 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 10, 2010, Canne Bannen, Lynne; Chan, Diva Sze-Ming; Gu, Xiao-Hui; Mac, Morrison B.; Ng, Stephanie; Wang, Tie-Lin; Wang, Yong; Xu, Wei published a patent.Application of 34662-29-8 The title of the patent was Imidazo[1,2a]pyridine derivatives, their use as S1P1 agonists and methods for their production. And the patent contained the following:

The invention is directed to compounds of formula I as well as methods of making and using the compounds Compounds of formula I wherein R1 is H, halo, CN, C1-6 alkoxy, amino, etc.; R2 is H, Me, and MeO; R3 is H, C1-6 alkyl, C1-6 alkylsulfonyl, halo, C1-6 haloalkyl, etc.; R4 is H and C1-6 alkyl; A is 5-membered heteroarylene; R5 is (un)substituted Ph and (un)substituted heteroaryl; and stereoisomers, mixtures of isomers, and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their S1P1 agonistic activity. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Application of 34662-29-8

The Article related to imidazopyridine preparation s1p1 agonist treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application of 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts