Month: November 2022

On December 31, 1994, Jeng, Huey-Jiuan; Fang, Jim-Min published an article.HPLC of Formula: 5098-14-6 The title of the article was Formation of pyrrole derivatives from heteroatom-substituted acetonitriles. And the article contained the following:

Aminomalononitrile reacted with conjugated carbonyl compounds to give 3H-pyrrolines. Treatment of 2-chloro-2-phenylthioacetonitrile with alkenes in the presence of potassium t-butoxide afforded 1-phenylthiocyclopropanecarbonitriles, which reacted with nucleophiles in 1,2-, 1,4- or 1,6-addition modes. The 1,2-adducts (cyclopropylimines) rearranged in situ to give substituted pyrroles. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).HPLC of Formula: 5098-14-6

The Article related to pyrrole derivative, heteroatom substituted acetonitrile reaction, aminomalononitrile reaction carbonyl compound, phenylthiocyclopropanecarbonitrile reaction nucleophile, Heterocyclic Compounds (One Hetero Atom): Pyrroles and Pyrrolizines and other aspects.HPLC of Formula: 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 31, 2009, Kaspady, Mohamed; Narayanaswamy, Venugopala Katharigatta; Raju, Mohana; Rao, Gopal Krishna published an article.Synthetic Route of 34662-29-8 The title of the article was Synthesis, antibacterial activity of 2,4-disubstituted oxazoles and thiazoles as bioisosteres. And the article contained the following:

Two series of 2-substituted aryl, heteroaryl and alkyl, 4-substituted aryl 1,3-oxazole (2a-k) and thiazole (4a-k) mol. scaffolds containing divalent bioisosteres, viz., oxygen and sulfur were synthesized by condensing substituted amides and thioamides with substituted phenacyl bromide in absolute ethanol medium. The structure of newly synthesized compounds was characterized by anal. and spectral (IR, 1H-NMR, 13C-NMR and LC-MS) methods. The synthesized compounds were evaluated for qual. (zone of inhibition) and quant. antibacterial activity (MIC) by agar cup plate and micro-titration methods, resp. Preliminary pharmacol. observations revealed that some of the substituents such as 2-alkyl and heteroaryl at second position, chloro and bromo at the fourth position of the aryl moiety and a divalent sulfur atom in the five-membered heterocyclic ring system influenced significantly the antibacterial activity when compared to its bioisostere counterpart 2-substituted aryl, heteroaryl and alkyl, 4-substituted aryl 1,3-oxazole systems. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Synthetic Route of 34662-29-8

The Article related to antibacterial oxazole thiazole preparation sar, Microbial, Algal, and Fungal Biochemistry: Antimicrobial Sensitivity and other aspects.Synthetic Route of 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Boche, Gernot; Mendiola, Javier; Rincon, Juan A.; Mateos, Carlos; Soriano, Jose Francisco; de Frutos, Oscar published an article in 2011, the title of the article was O-(mesitylsulfonyl)hydroxylamine.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate And the article contains the following content:

Synthesis, properties and applications of O-(mesitylsulfonyl)hydroxylamine as a reagent for electrophilic aminations, and for transfer of NH2 to electrophiles were reviewed. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to review mesitylsulfonyl hydroxylamine preparation amination amino group transfer, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Reviews and other aspects.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On September 30, 2012, Gabrielli, Serena; Palmieri, Alessandro; Panmand, Deepak S.; Lanari, Daniela; Vaccaro, Luigi; Ballini, Roberto published an article.SDS of cas: 2510-01-2 The title of the article was β-Nitroacrylates as key starting materials for the one-pot synthesis of densely functionalized penta-substituted anilines. And the article contained the following:

The reaction of ylidene malononitriles with β-nitroacrylates, in Et3N/MeCN, affords the one-pot synthesis of a new class of penta-substituted, densely-functionalized anilines in satisfactory to good overall yields. The method represents a very important improvement of the recent strategy for the preparation of anilines from conjugated nitro alkenes. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).SDS of cas: 2510-01-2

The Article related to nitroacrylate ylidene malononitrile conjugate addition, aniline substituted preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: General and other aspects.SDS of cas: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 7, 1999, Konstantinova, Lidia S.; Rakitin, Oleg A.; Souvorova, Ljudmila I.; Rees, Charles W.; White, Andrew J. P.; Williams, David J.; Torroba, Tomas published an article.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was One-pot synthesis of new liquid crystalline indeno heterocyclic materials. And the article contained the following:

Disulfur dichloride converts 1-(dicyanomethylene)indane into 2,3-dichloro-1-(dicyanomethylene)indene and dichlorocyanoindeno-1,2-thiazine (I); it also converts inden-3-ylacetic acid into 2,3-dichloro-1-(dichloromethylene)indene and α,2,3-trichloro-1-indenylideneacetylchloride, dichloroindeno[2,1-c]-1,2-dithiolone (II) and dichloroindenothiophenone; upon melting crystals of the 2,3-dichloro-1-(dichloromethylene)indene and dichloroindenothiophenone are strongly birefringent and I exhibits thermochromicity; mechanisms are outlined for the novel transformations and x-ray crystal structures for I and II are analyzed. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to one pot synthesis liquid crystal indeno heterocyclic compound, Crystallography and Liquid Crystals: Liquid Crystals, Plastic Crystals and other aspects.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On September 5, 2005, Basurto, Sara; Garcia, Susana; Neo, Ana G.; Torroba, Tomas; Marcos, Carlos F.; Miguel, Daniel; Barbera, Joaquin; Ros, M. Blanca; de la Fuente, M. Rosario published an article.Application of 2510-01-2 The title of the article was Indene and pseudoazulene discotic liquid crystals: A synthetic and structural study. And the article contained the following:

Several new liquid-crystalline indene and pseudoazulene systems are reported. These mols. give rise to either columnar hexagonal mesophases and/or columnar plastic phases. The unique nature of these compounds stems from their nonclassical discotic structure. Although the mols. have rigid aromatic cores, they lack terminal tails and instead the polarizable atoms (S, halogens) or polar groups (CN, CO) act as unusual soft parts. From many structurally related materials, for this type of compound mol. stacking in the solid state is a prerequisite for the appearance of a columnar mesophase, although other intermol. interactions within the layers are also important in establishing liquid-crystalline order. The behavior reported for these mesomorphic mols. opens up new possibilities in the search for related mol. interactions that might be useful for the construction of supramol. architectures with particular properties. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application of 2510-01-2

The Article related to indene pseudoazulene discotic liquid crystal structure property, Crystallography and Liquid Crystals: Liquid Crystals, Plastic Crystals and other aspects.Application of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On March 2, 2016, Bujok, Robert; Wrobel, Zbigniew; Wojciechowski, Krzysztof published an article.Reference of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile The title of the article was Simple synthesis of 4-cyanoquinoline N-oxides. And the article contained the following:

4-Cyanoquinoline-N-oxides I (X = H, Cl, CF3, CN; Y = H, Cl, I, F, CF3, Ph, SPh, SMe; Z = H, Br) were obtained in the reactions of 2-nitrobenzyl cyanide carbanions with acrylonitrile. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Reference of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile

The Article related to nitrobenzyl cyanide acrylonitrile base, cyanoquinoline oxide preparation, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Reference of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 3, 2011, Shibata, Norio; Kagawa, Takumi published a patent.Category: nitriles-buliding-blocks The title of the patent was preparation of trifluoromethylthiophenium derivative salts as trifluoromethylating agents. And the patent contained the following:

Provided are trifluoromethylthiophenium derivative salts useful as intermediates in the synthesis of drugs or agricultural chems., a process for production of the same, and a process for the production of trifluoromethyl-containing compounds using the same as the trifluoromethylating agent. Specifically, S-(trifluoromethyl) -benzo[b]thiophenium derivative salts represented by general formula I [ R1-4 = H, C1-10 alkyl, C1-10 alkoxy, F, Cl, Br, NO2, CN; R5 = C1-10 alkyl, (substituted) phenyl; X = anion] is prepared by reacting trifluoromethyl 2-ethynylphenyl sulfide II with an acid. Thus, 2-cyclopropyl-1-trifluoromethylbenzo[b]thiophenium triflate was prepared by reacting 1-cyclopropylethynyl-2-trifluoromethylsulfanylbenzene with trifluoromethanesulfonic acid. When Me 1-indanone-2-carboxylate was treated with 2-cyclopropyl-1-trifluoromethylbenzo[b]thiophenium triflate, 1-oxo-2-trifluoromethylindan-2-carboxylic acid Me ester was obtained. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Category: nitriles-buliding-blocks

The Article related to trifluoromethylthiophenium derivative salt preparation trifluoromethylating agent, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenothiophenes and other aspects.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 17, 2022, Li, Chao; Wang, He; Liu, Lu; Sun, Ran; Wang, Xin; Zhou, Ming-Dong; Li, Lei published an article.COA of Formula: C9H5F3N2O2 The title of the article was Base-Catalyzed Intramolecular Self-Cyclization of o-Alkenylaryl Isocyanides: Access to 4-Cyano-3-arylquinolines. And the article contained the following:

A novel base-catalyzed intramol. self-cyclization reaction of o-alkenylaryl isocyanides [2-N+C–C6H3(R)-C(CN)(=CHR1)] (R = H, 3-Cl, 4-F, 5-Me, etc.; R1 = Ph, 4-chlorophenyl, 3,4-dimethylphenyl, 2-naphthyl, thiophen-2-yl, etc.) has been successfully developed. This reaction provides a general, efficient and atom-economic method to access 4-cyano-3-arylquinolines I (R2 = H, 8-Cl, 7-F, 6-Me, etc.) with broad scope of substrates and excellent functional group compatibilities. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).COA of Formula: C9H5F3N2O2

The Article related to aryl quinoline preparation, alkenylaryl isocyanide tandem heterocyclization cesium carbonate catalyst, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.COA of Formula: C9H5F3N2O2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On July 1, 2010, Li, Jianqi; Wang, Guan; Zhang, Guisen; Lv, Na; Jiao, Guangjun; Liu, Shicheng; Zhou, Shixia published a patent.Electric Literature of 34662-29-8 The title of the patent was Preparation of piperidinyl benzisoxazole derivatives as inhibitors of 5-HT2A receptor. And the patent contained the following:

The invention provides piperidinyl benzisoxazole derivatives with formula I [R = H, halo, (un)substituted alkyl, or alkoxy; X and Y independently = CH or N; Ra = H, halo, CN, (un)substituted alkyl, alkoxy, etc,], and their salts and hydrates, are prepared and disclosed. The invention compounds has antagonistic effect on 5-HT2A and has mediating effect on 5-hydroxytryptamine system such as reuptake inhibiting effect of 5-HT and so on. Thus, e.g., II was prepared by condensation reaction of N-(4-chlorobutyl)indole with 4-(6-fluorobenzisoxazol-3-yl)piperidine. II exhibited affinity to 5-HT2A with IC50 value of 1.659 nM and Ki value of 1.9806 nM. The compounds of the invention possess excellent analgesia, sedation activity, minimal toxicity and side effects. The invention also provides pharmaceutical compositions comprising the derivatives and their use. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Electric Literature of 34662-29-8

The Article related to benzisoxazole piperidinyl preparation 5hta receptor inhibitor pain, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Electric Literature of 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts