Allen, Joanne V. published the artcileThe discovery of benzanilides as c-Met receptor tyrosine kinase inhibitors by a directed screening approach, Synthetic Route of 612-13-5, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(18), 5224-5229, database is CAplus and MEDLINE.
A directed screen of a relatively small number of compounds, selected for kinase ATP pocket binding potential, yielded a novel series of hit compounds (1). Hit explosion on two binding residues identified compounds 27 and 43 as the best leads for an optimization program having reduced secondary metabolism, as measured by in vitro rat hepatocytes incubation, leading to oral bio-availability. Structure-activity relationships and mol. modeling have suggested a binding mode for the most potent inhibitor 12.
Bioorganic & Medicinal Chemistry Letters published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Synthetic Route of 612-13-5.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts