Bartlett, Robert T.’s team published research in Journal of Medicinal Chemistry in 24 | CAS: 5098-14-6

Bartlett, Robert T. published the artcileSynthesis and pharmacological evaluation of a series of analogs of 1-methylisoguanosine, Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate, the publication is Journal of Medicinal Chemistry (1981), 24(8), 947-54, database is CAplus and MEDLINE.

Analogs of 1-methylisoguanosine (I, R = Me, R¹ = H, R² = OH) were evaluated as muscle relaxants, antiinflammatory agents, allergy inhibitors, and for cardiovascular activity. Cyclizing imidazole nucleoside II with RNCO (R = Et, Bu, octyl, Ph) and deprotecting gave I (R = Et, Bu, octyl, Ph; R¹ = H, R² = OH). Bromination of I (R = Me, R¹ = H, R² = OH) with Br₂-H₂O gave I (R = Me, R¹ = Br, R² = OH) which reacted with N₂H₄ to give I (R = Me, R¹ = NHNH₂, R² = OH). This was cleaved with Raney Ni to give I (R = Me, R¹ = NH₂, R² = OH). Deamination of 1-methylguanosine with NaNO₂ in aqueous AcOH gave 1-methylxanthosine. Iodination of I (R = Me, R¹ = H, R² = OH) with Me(PhO)₃P⁺I^– gave I (R = Me, R¹ = H, R² = iodo) which was cyclized to III or deiodinated to I (R = Me, R¹ = R² = H). The phosphate ester I (R = Me, R¹ = H, R² = OPO₃^2-) was prepared as well as cyclic phosphate IV. C-Nucleoside V was prepared from Me β-D-ribofuranosyl-1-carboximidate. Cyclizing the 9-(2-hydroxyethoxy)methyl analog of II with MeNCO gave acyclic analog VI. Similarly prepared was the β-D-arabinofuranosyl analog of I (R = Me, R¹ = H, R² = OH).

Journal of Medicinal Chemistry published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts