Taylor, Edward C. published the artcilePteridines. 48. Utilization of 3,3-dimethoxy-2-pyrrolidinopropene for the synthesis of folic acid, N2‘-acetyl-7-folic acid, and 5-deaza-7-folic acid, Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate, the publication is Journal of Organic Chemistry (1981), 46(7), 1394-402, database is CAplus.
Pyrrolidinopropene I was treated with NOCl and hydrolyzed to give (MeO)2CHCOCH:NOH which was treated with NCCH(NH2)CN to give II, a known precursor for III (R = CHO, R1 = H). Treating I with 4-MeC6H4SO3N:C(CN)2 and then with NH4OH gave IV [R2 = H, R3 = (MeO)2CH] which gave III (R = H, R1 = CHO) (V) by guanidine cyclization. VI (R4 = CHO, R5 = H, X = CH) was prepared by treating I with MeOCH:C(CN)2 followed by cyclizing with NH4OH to give VII which was treated with HN:C(NH2)2, NaOH, and then HCl. Refluxing V with Ac2O followed by condensation with 4-H2NC6H4COGlu(OCMe3)OCMe3 gave VI (R4 = CH:NC6H4CO-Glu(OCMe3)OCMe3-4, R5 = Ac, X = N] which was reduced by NaBH4 to give 37% VI (R4 = CH2NHC6H4CO-Glu(OCMe3)OCMe3-4]. Similarly refluxing VI (R4 = CHO, R5 = H, X = CH) with 4-H2NC6H4CO-Glu(OMe)OMe followed by reduction by NaBH4 gave ∼40% VI [R4 = CH2NHC6H4CO-Glu(OMe)OMe-4].
Journal of Organic Chemistry published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C8H8O3, Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts