Kang, Taeho published the artcileNickel-Catalyzed 1,2-Carboamination of Alkenyl Alcohols, Recommanded Product: 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, the publication is Journal of the American Chemical Society (2021), 143(34), 13962-13970, database is CAplus and MEDLINE.
An alc.-directed, nickel-catalyzed three-component umpolung carboamination of unactivated alkenes with aryl/alkenylboronic esters and electrophilic aminating reagents was reported. This transformation was enabled by specifically tailored O-(2,6-dimethoxybenzoyl)hydroxylamine electrophiles that suppressed competitive processes, including undesired β-hydride elimination and transesterification between the alc. substrate and electrophile. The reaction delivered the desired 1,2-carboaminated products with generally high regio- and syn-diastereoselectivity and exhibited a broad scope of coupling partners and alkenes, including complex natural products. Various mechanistic experiments and anal. of the stereochem. outcome with a cyclic alkene substrate, as confirmed by X-ray crystallog. anal., support alc.-directed syn-insertion of an organonickel(I) species.
Journal of the American Chemical Society published new progress about 214360-44-8. 214360-44-8 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, and the molecular formula is C12H14BNO2, Recommanded Product: 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
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