Zhang, Hong-Jian published the artcileSynthesis and pharmacological evaluation of new 3,4-dihydroisoquinolin derivatives containing heterocycle as potential anticonvulsant agents, Formula: C8H6ClN, the publication is Molecules (2016), 21(12), 1635-1650, database is CAplus and MEDLINE.
Novel, fused 3,4-dihydroisoquinolines I (R1 = H, Me, n-C5H11, etc.) and II [R2 = n-C6H13 (III), n-C7H15, n-C8H17, PhCH2, 4-ClC6H4CH2] were synthesized and evaluated for their anticonvulsant activity using maximal electroshock (MES) test and pentylenetetrazole (PTZ)-induced seizure test. Among them, compound III showed significant anticonvulsant activity in MES tests with an ED50 value of 63.31 mg/kg and it showed wide margins of safety with protective index (PI > 7.9). Compound III showed much higher anticonvulsant activity than that of valproate. Compound III also demonstrated potent activity against PTZ-induced seizures. A docking study of compound III in the benzodiazepine (BZD)-binding site of γ-aminobutyric acidA (GABAA) receptor confirmed possible binding of compound with the BZD receptors.
Molecules published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C5H7NO, Formula: C8H6ClN.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts