Biswas, Soumen published the artcileDiastereoselective pot- and atom-economical synthesis of densely-substituted polycyclic 1,2- and 1,2,3-fused indole scaffolds, Application of (E)-4-(2-Nitrovinyl)benzonitrile, the publication is Tetrahedron Letters (2019), 60(32), 150921, database is CAplus.
A simple, efficient, one-pot sequential process for the preparation of a family of 8,9-dihydropyrido[1,2-a]indol-6(7H)-one scaffolds I [R1 = Ph, 2-ClC6H4, 2-furyl, etc.; stereo = cis, trans] in acceptable yields was established under mild conditions. The Michael-hemiaminalization-oxidation reaction proceeded between Me 2-(3-formyl-1H-indol-2-yl) acetate and trans-β-aryl/alkyl-substituted acroleins using pyrrolidine-BzOH as an efficient organocatalyst, followed by oxidation of in situ generated of C,N-fused hemiaminal adducts in the presence of PDC at room temperature Excitingly, organobase-catalyzed highly diastereoselective (up to ≤9:1 dr) construction of a series of pharmacol. attractive 1,2,3-fused tetracyclic indole scaffolds with five contiguous chiral centers including an all-carbon stereogenic center II [R2 = CO2Me, Ph, 2-furyl, etc.; R3 = Ph, 4-MeOC6H4] was achieved using developed method. Moreover, pyrrolidine-BzOH and PTSA as combined catalytic systems promoted the uninterrupted sequential Michael-cyclization reaction, followed by N-alkylation reaction with carbazole to produce interesting class of 6-(9H-carbazol-9-yl)-6,7,8,9-tetrahydropyrido[1,2-a]indole derivatives III [R3 = Ph, 4-MeOC6H4] in a diastereoselective manner.
Tetrahedron Letters published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Application of (E)-4-(2-Nitrovinyl)benzonitrile.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts