Lei, Zhen-lin published the artcileSynthesis with solvent-free and antifungal activities of 6-ether coumarin derivatives, Application In Synthesis of 612-13-5, the publication is Nongyao (2015), 54(10), 724-726, 743, database is CAplus.
2-Methyl-4-benzenediol was reacted with Et acetoacetate via Pechmann condensation to yield 6-hydroxy-4,7-dimethyl-coumarin, then the coumarin grinded with substituted benzyl chloride without solvent to yield twelve title compounds 4a-4l. The structure of the compounds were confirmed by 1H NMR and LC-MS. The preliminary bioassay indicated some compounds, such as 4b, 4c and 4e, displayed over 90% antifungal activities against Botryodiplodia theobromae at 100 mg/L.
Nongyao published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Application In Synthesis of 612-13-5.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts