Spectrographic method for the detection of active methylene groups and synthesis of several styrene and stilbene derivatives. VII. Bromo derivatives of phenylacetonitrile was written by Areschka, Alex;Bruylants, Albert. And the article was included in Bulletin de la Societe Chimique de France in 1958.SDS of cas: 67197-53-9 This article mentions the following:
By the same methods as in the preceding abstract the order of decreasing acidity of the cyanomethyl group in Br derivatives of PhCH2CN is 4-Br > 2,4-di-Br > 2-Br > 2,4,6-tri-Br > 2,6-di-Br. The rate of formation and yields of cyanostilbenes from these compounds and BzH (I) or p-Me2NC6H4CHO (II) decrease in the order of decreasing acidity (Br location, aldehyde, reaction time in days, yield of cyanostilbene, and m.p. are given): 4-, I, 0, 99, 109-12°, 129-54.5° (geometric isomers); 4-, II, 0, 99, 193-3.5°; 2,4-, I, 45 min., 99, 141-2°; 2,4-, II, 1, 82, 126-7°; 2-, I, 1, 64, 71.5-2°; 2-, II, 1, 60, 137-9°; 2,4,6-, I, 8, 43, 132.8-144.8°; 2,4,6-, II, 8, 30, 164.5-5.5°; 2,6-, I, 8, 27, 118.5-20°; 2,6-, II, 8, 24, 187-8.5°. 2,4-Br2C6H3CH2CN, m. 83.5-4.5°, is prepared in 24% yield from 3-H2NC6H4Me by acetylation, bromination, deacetylation, deamination, side chain bromination and cyanation, and the 2,6-di-Br isomer, m. 97-7.5°, in 15% yield from 4-O2NC6H4CH3 by bromination, reduction, deamination, side chain bromination and cyanation. A new synthesis of 2,4,6-Br3C6H2CH2CN from 3-O2NC6H4CH2CN by reduction, bromination, and deamination is given. In the experiment, the researchers used many compounds, for example, 2-(2,6-Dibromophenyl)acetonitrile (cas: 67197-53-9SDS of cas: 67197-53-9).
2-(2,6-Dibromophenyl)acetonitrile (cas: 67197-53-9) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.SDS of cas: 67197-53-9
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts