Month: December 2022

Kapustin, A. I. published the artcileSimultaneous application of 2M-4XM (Tropotox) and superphosphate in clover cultivation, HPLC of Formula: 3336-34-3, the publication is Khim. v Sel’sk. Khoz. (1965), 3(11), 41-4, database is CAplus.

Herbicidal activity of Tropotox (I) in combination with superphosphate was studied on a 2-year-old cultivation of pink clover. The soil on the lot was soddy podzolic, sandy-silty clay, containing 4% of humus, 6 mg. of P and, 16 mg. of K/100 g. of soil, 75% saturated with alk. materials, pH 5.6. I at 4 kg./ha. was most effective against dicotyledonous perennials, e.g. yellow thistle and bindweed (reduced to half the control amount). Combination of I (4 kg./ha.) and superphosphate (10 kg./ha. of P₂O₅) was even more effective, killing 85% of the above weeds. I was also effective against dicotyledonous annuals, but in combination with superphosphate its effectiveness dropped. During the first 5-10 days after application of I, the growth of clover was slightly suppressed, but it then continued in a normal manner. I at 4 kg./ha. alone and in mixture with 10 kg. superphosphate/ha. does not affect the quality of clover seeds. At large doses of I (6 kg./ha.), the seed were impaired.

Khim. v Sel’sk. Khoz. published new progress about 3336-34-3. 3336-34-3 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Phenol, name is 2,6-Dichloro-3-hydroxybenzonitrile, and the molecular formula is C7H3Cl2NO, HPLC of Formula: 3336-34-3.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Ikeda, Yoshitsugu published the artcileReactions of acyl peroxides. I. The photochemical decomposition of benzoyl peroxide in glacial acetic acid, Application In Synthesis of 13312-84-0, the publication is Nippon Kagaku Zasshi (1958), 354-8, database is CAplus.

Bz₂O₂ (I) (24.2 g.) in 1 l. HOAc was irradiated by light (2537 A.) 50 hrs. at 20°. At the end of this period, unreacted I was less than 0.5 g., and CO₂, which was removed and absorbed in KOH as it was evolved, was 1.85 g. from 2 runs. Fractional distillation gave 5 g. C₆H₆. (CH₂CO₂H)₂ (2.3 g.) was first obtained from the residue and steam distillation yielded 9.1 g. BzOH and 15.9 g. neutral substance (II). The residue from the steam distillation gave 1.1 g. neutral substance (III), 1.2 g. homophthalic acid (IV), 0.9 g. homoisophthalic acid (V), 1.5 g. homoterephthalic acid (VI), 2.3 g. p-PhC₆H₄CO₂H (VII), and 5.1 g. resinous material. II and III gave 3.8 g. Ph₂, 2.2 g. BzOH, and 1.8 g. PhOH. Thus II and III were mixtures of Ph₂ and BzOPh. Thermal decomposition of I was neglected because the rate was too small. The products were related as follows. I decomposed to BzO• (VIII). VIII decomposed to Ph• and CO₂ and with AcOH produced BzOH and •CH₂CO₂H (IX). Ph• also reacted with AcOH to produce C₆H₆ and IX. IX combined to produce (CH₂CO₂H)₂ and reacted with BzOH to give VI. VIII and IX gave IV, V, and VI, which were also produced from I and IX. The formation of BzOPh and Ph₂ was attributed to induced decomposition of I and to the recombination of VIII and Ph• or Ph• itself because of the accumulation at rather low temperature

Nippon Kagaku Zasshi published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Application In Synthesis of 13312-84-0.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Ferris, James P. published the artcileStudies in prebiotic synthesis. I. Aminomalononitrile and 4-amino-5-cyanoimidazole, Name: 2-Aminomalononitrile 4-methylbenzenesulfonate, the publication is Journal of the American Chemical Society (1966), 88(16), 3829-31, database is CAplus and MEDLINE.

The syntheses of aminomalononitrile and 4-amino-5-cyanoimidazole are described. Acid anhydrides react with aminomalononitrile to yield oxazoles. Aminomalononitrile is converted to diaminomaleonitrile by cyanide and to 4-amino-5-cyanoimidazole by formamidine. Adenine results from the reaction of 4-amino-5-cyanoimidazole with formamidine. 4-Cyano-5-aminooxazole is converted to 7-aminooxazolo[5,4-d]pyrimidine on treatment with formamidine. 16 references.

Journal of the American Chemical Society published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, Name: 2-Aminomalononitrile 4-methylbenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Buck, Johannes S. published the artcileCatalytic reduction of mandelonitriles, Formula: C8H6ClNO, the publication is Journal of the American Chemical Society (1933), 2593-7, database is CAplus.

In the presence of a slight excess of concentrated HCl, mandelonitriles in EtOH are smoothly reduced catalytically to the corresponding β-phenylethylamine or the β-HO derivative; the reaction is complex and although some of the yields are not satisfactory, the expediency of the method makes it convenient for the preparation of certain amines. The following mandelonitriles were prepared: o-MeO, m. 73°, 65% yield; o-Cl, m. 47° (73%); 2,3-di-MeO, m. 79° (54%); p-MeO, m. 67° (62%); 3,4-di-MeO, m. 103° (78%); p-Cl, m. 43° (81%); carbomethoxy, b₃ 136°, d₄²⁵ 1.1735, n_D²⁵ 1.5000; p-methoxycarbethoxy, b_2-1 170°, d. 1.1683, n 1.5063; o-chlorocarbethoxy, b_1.4 145°, d. 1.2444, n 1.5115. In the reduction those nitriles with o-substituents give the β-hydroxyamine, the others give the amine. The following HCl salts of β-phenylethylamines were prepared: o-methoxy-β-hydroxy, m. 184° (59% yield) (p-nitrobenzoyl derivative, pale yellow, m. 178°); o-chloro-β-hydroxy, m. 197° (41%; p-nitrobenzoyl derivative, m. 194°); 2,3-dimethoxy-β-hydroxy, m. 134° (23.5%; p-nitrobenzoyl derivative, pale yellow, m. 178°); o-Cl, flows 204° (94%; p-nitrobenzoyl derivative, m. 112°); p-dimethylamino, froths 238° (44%; Bz derivative, lemon-yellow, m. 130°); p-MeO, 52% from p-MeOC₆H₄CH:CHCN and 49% from MeO₂CC₆H₄CH:CHCN (p-nitrobenzoyl derivative, pale yellow or bright orange, m. 145°); 3,4-di-MeO, m. 151° (52%; p-nitrobenzoyl derivative, pale lemon, m. 147°); p-Cl, orange, m. 195° (50%; Bz derivative, m. 147°); the p-nitrobenzoyl derivative of the o-MeO derivative, pale yellow, m. 138°.

Journal of the American Chemical Society published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Formula: C8H6ClNO.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Armarego, Wilfred L. F. published the artcilePterins. Part 2. Stereochemistry of catalytic reduction of 6-methyl- and 6,7-dimethyl-pterin and of 2,4-diamino-6-methylpteridine, Computed Properties of 5098-14-6, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1977), 2529-36, database is CAplus.

Catalytic addition of 2 mols. of H to 7-deuterio-6-trideuteriomethylpterin gave a 0.8:1 mixture of cis– and trans-7-deuterio-6-trideuteriomethyl-5,6,7,8-tetrahydropterin. Similar reduction of 2,4-diamino-7-deuterio-6-(partial)trideuteriomethylpteridine gave a 1:1 mixture of cis– and trans-2,4-diamino-7-deuterio-6-(partial)trideuteriomethyl-5,6,7,8-tetrahydropteridine. However, catalytic reduction of 6,7-dimethyl- and 6,7-bis(trideuteriomethyl)pterin is stereospecific and gave only the cis 5,6,7,8-tetrahydro derivatives Reduction of 6,7-dimethylpterin with Na in EtOH gave a 1:1 mixture of cis– and trans-6,7-dimethyl-5,6,7,8-tetrahydropterin. The stereochem. of the products was deduced from ¹H NMR spectroscopy.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, Computed Properties of 5098-14-6.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Mlotkowska, B. published the artcileSolid sodium hydroxide/potassium carbonate – a new highly effective base for phase-transfer catalyzed N-alkylation of diphenylphosphinic hydrazide, HPLC of Formula: 49540-34-3, the publication is Tetrahedron Letters (1978), 4731-4, database is CAplus.

Ph₂P(O)NHNH₂ underwent phase-transfer-catalyzed N-alkylation with RBr (R = Me, Et, Pr, iso-Pr, Bu, iso-Bu, sec-Bu, CH₂:CHCH₂, CHCCH₂, CH₂Ph) in boiling C₆H₆ containing solid NaOH-K₂CO₃, to give 27-94% Ph₂P(O)NRNH₂ (I). Subsequent treatment of I (R = Et, Pr, iso-Pr, Bu, CH₂:CHCH₂, CH₂Ph) with 15% HCl gave Ph₂P(O)OH and 82-99% RNHNH₂.2HCl.

Tetrahedron Letters published new progress about 49540-34-3. 49540-34-3 belongs to nitriles-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethylhydrazine dihydrochloride, and the molecular formula is C2H10Cl2N2, HPLC of Formula: 49540-34-3.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Vitkovska, Viktorija published the artcileAliphatic chain-containing macrocycles as diazonamide A analogs, Name: 2-Aminomalononitrile 4-methylbenzenesulfonate, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2020), 56(5), 586-602, database is CAplus.

Aliphatic alkyl chain-containing 12-14-membered macrocycles were designed as structural analogs of antimitotic natural product diazonamide A. Macrocycles were synthesized from 5-bromooxazole in 7 to 9 linear steps using Ru-catalyzed ring-closing metathesis as the key transformation. Heat effect of binding to α,β-tubulin tetramer (T4-RB3 complex) has been measured for the synthesized macrocycles by isothermal titration calorimetry method.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C8H7NO4, Name: 2-Aminomalononitrile 4-methylbenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

DeSantis, Grace published the artcileAn enzyme library approach to biocatalysis: development of nitrilases for enantioselective production of carboxylic acid derivatives, Related Products of nitriles-buliding-blocks, the publication is Journal of the American Chemical Society (2002), 124(31), 9024-9025, database is CAplus and MEDLINE.

The discovery, from nature, of a large and diverse set of nitrilases is reported. The utility of this nitrilase library for identifying enzymes that catalyze efficient production of valuable hydroxy carboxylic acid derivatives is demonstrated. Unprecedented enantioselectivity and substrate scope are highlighted for 3 newly discovered and distinct nitrilases. For example, a wide array of (R)-mandelic acid derivatives and analogs were produced with high rates, yields, and enantiomeric excesses (95-99% ee). We also have found nitrilases that provide direct access to (S)-phenyllactic acid and other aryllactic acid derivatives, again with high yields and enantioselectivities. Finally, different nitrilases have been discovered that catalyze enantiotopic hydrolysis of 3-hydroxyglutaronitrile to afford either enantiomer of 4-cyano-3-hydroxybutyric acid with high enantiomeric excesses (>95% ee). The 1st enzymes are reported that effect this transformation to furnish the (R)-4-cyano-3-hydroxybutyric acid, which is a precursor to the blockbuster drug Lipitor.

Journal of the American Chemical Society published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Related Products of nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zhang, Ying published the artcileHierarchical self-assembly of alkynylplatinum(II) bzimpy functionalized metallacage via Pt···Pt and π-π interactions, Recommanded Product: Tetrakis(acetonitrile)palladium(II) Ditriflate, the publication is Inorganic Chemistry (2018), 57(7), 3516-3520, database is CAplus and MEDLINE.

A new discrete supramol. metallacage functionalized with an alkynylplatinum(II) 2,6-bis(benzimidazole-2′-yl)-pyridine (bzimpy) moiety has been successfully constructed via coordination-driven self-assembly. A study on the hierarchical self-assembly behavior of the obtained metallacage revealed that it displayed a solvent-induced emission switch accompanied by enhancement of the emission intensity as a result of the change in intermol. Pt···Pt and π-π interactions. More interestingly, the metallacage has been found to spontaneously self-assemble into a transparent metallogel at room temperature without a heating-cooling process.

Inorganic Chemistry published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C14H10O4S2, Recommanded Product: Tetrakis(acetonitrile)palladium(II) Ditriflate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Chen, Zhen published the artcileUse of a Traceless Activating and Directing Group for the Construction of Trifluoromethylpyrazoles: One-Pot Transformation of Nitroolefins and Trifluorodiazoethane, Quality Control of 5153-73-1, the publication is Angewandte Chemie, International Edition (2017), 56(16), 4569-4574, database is CAplus and MEDLINE.

We disclose an efficient one-pot transformation of trifluorodiazoethane and higher perfluorinated homologues with various nitroolefins. This method takes advantage of the nitro group as a traceless activating and directing group (TADG) that is released in the aromatization step to produce 4-substituted 3-perfluoroalkyl pyrazoles with complete regioselectivity [e.g, trans-β-nitrostyrene + CF₃CHN₂ → pyrazole I (89%) in presence of Ag₂O and Na₃PO₄]. The potential of this method is further demonstrated by the synthesis of penthiopyrad. Safety: 2,2,2-trifluorodiazoethane is potentially explosive.

Angewandte Chemie, International Edition published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Quality Control of 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts