Month: December 2022

Alagoz, Dilek published the artcilePurification, immobilization and characterization of (R)-hydroxynitrile lyase from Prunus amygdalus turcomanica seeds and their applicability for synthesis of enantiopure cyanohydrins, SDS of cas: 13312-84-0, the publication is Journal of Molecular Catalysis B: Enzymatic (2014), 40-46, database is CAplus.

A hydroxynitrile lyase (HNL) was purified from wild almond seeds (Prunus amygdalus turcomanica Lincz.) for the first time. Native and subunit mol. masses of the HNL were determined as 100 and 25 kDa, resp. indicating that the enzyme is a homotetramer. The purified enzyme was immobilized onto Eupergit CM and Eupergit C 250 L supports and their lyase and carboligation (synthetic) activities were characterized in terms of optimal pH, temperature and kinetic parameters. While the optimal pH of the free HNL for the lyase activity was 6.0, it was 5.5 for both of the immobilized HNLs. Optimal temperature was determined as 25 °C for all HNL preparations For mandelonitrile cleavage, the apparent K_m – V_max values were 0.38 mM – 197.0 U mg protein^-1 for the free HNL, 1.30 mM – 26.0 U mg protein^-1 for HNL immobilized onto Eupergit CM (HNL-Eup CM) and 0.95 mM – 17.5 U mg protein^-1 for HNL immobilized onto Eupergit C 250 L (HNL-Eup C 250 L), resp. For the carboligation activity, the optimal pH was measured as 4.0 and optimal temperature was determined as 5 °C for all of the HNL preparations For mandelonitrile synthesis, the apparent K_m – V_max values were 14.0 mM – 2.70 U mg protein^-1 for the free HNL, 41.0 mM – 0.49 U mg protein^-1 for HNL-Eup CM and 38.0 mM – 0.54 U mg protein^-1 for HNL-Eup C 250 L, resp. All of the HNL preparations were employed for the synthesis of mandelonitrile, 2-chloromandelonitrile, 3,4-dihydroxymandelonitrile and 2-hydroxy-4-Ph butyronitrile in a biphasic tert-Bu Me ether-citrate buffer (pH 4.0) medium. The results showed that the immobilized HNL preparations were better than the free HNL in the synthesis of abovementioned cyanohydrins except 2-chloromandelonitrile with higher yields and enantiopurities.

Journal of Molecular Catalysis B: Enzymatic published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, SDS of cas: 13312-84-0.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Surzur, Jean M. published the artcileRadical addition to unsaturated alcohols. IV. Synthesis of 4-cyano-4-carbethoxytetrahydropyrans by intramolecular radical addition, SDS of cas: 30431-99-3, the publication is Bulletin de la Societe Chimique de France (1970), 3070-5, database is CAplus.

Esters (I) (Y = CN) were cyclized with Bz2O2 in refluxing cyclohexane. After decomposition of the excess peroxide, the products were distilled to sep. cyclohexane and the telomers. The distillate was analyzed by vapor-phase chromatog. I (m = 2, n = 0, R = H,Me) gave 71-88% tetrahydropyran derivative (II). I (m = 2; n = 1; R and R1 = H (or Me) gave 96-98% tetrahydropyran derivatives and no 7-membered heterocyclic O-containing compounds could be detected. I (m = n = 1, R = H and Me, and X = CO2Et, Y = CO2Et and CN) gave only polymerized products. This type of reaction gave substituted tetrahydropyran or tetrahydrofuran derivatives which are often not readily accessible by other methods. However, the presence of the O atom makes it necessary to operate at very high dilutions and to use longer reaction times if polymerization, is to be avoided.

Bulletin de la Societe Chimique de France published new progress about 30431-99-3. 30431-99-3 belongs to nitriles-buliding-blocks, auxiliary class Tetrahydropyran,Nitrile,Ester, name is Ethyl 4-cyanotetrahydro-2H-pyran-4-carboxylate, and the molecular formula is C8H7NO4, SDS of cas: 30431-99-3.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kita, Yusuke published the artcileRhodium-Catalyzed Alkenylation of Nitriles via Silicon-Assisted C-CN Bond Cleavage, Category: nitriles-buliding-blocks, the publication is Organic Letters (2010), 12(8), 1864-1867, database is CAplus and MEDLINE.

Rhodium-catalyzed Mizoroki-Heck type reaction of nitriles via the cleavage of C-C bonds is described. Orthogonal and iterative functionalizations of arenes were also demonstrated by combining the present and conventional halide-based cross-coupling reactions.

Organic Letters published new progress about 214360-44-8. 214360-44-8 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, and the molecular formula is C12H14BNO2, Category: nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kita, Yusuke published the artcileRhodium-catalyzed carbon-cyano bond cleavage reactions using organosilicon reagents, SDS of cas: 214360-44-8, the publication is Yuki Gosei Kagaku Kyokaishi (2010), 68(11), 1112-1122, database is CAplus.

Rh-catalyzed C-cyano bond cleavage reactions using organosilicon reagents are described. When disilane is used as the Si reagent, the C-CN bonds in aryl and alkenyl cyanides are silylated to form the corresponding silylated products along with silyl cyanide. Reductive decyanation of nitriles is achieved when hydrosilane is used as the Si reagent. This catalytic system can be applied to the C(sp³)-CN bonds in simple aliphatic nitriles. In both reactions, the silylrhodium species generated in situ serves as a catalytically active species, cleaving C-CN bonds via an η²-iminoacyl complex. Addition of external electrophiles allowed the Si-assisted cleavage of C-CN bonds to be applied to C-C bond formation reactions. Intramol. arylation of benzonitrile bearing a tethered chlorophenyl group and decyanative Mizoroki-Heck-type alkenylation of nitriles with vinylsilanes have been developed.

Yuki Gosei Kagaku Kyokaishi published new progress about 214360-44-8. 214360-44-8 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, and the molecular formula is C12H14BNO2, SDS of cas: 214360-44-8.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Shyshkina, Olena O. published the artcileA novel synthesis and transformations of isothiochroman 2,2-dioxide, Recommanded Product: 2-(Chloromethyl)benzonitrile, the publication is Tetrahedron Letters (2012), 53(33), 4296-4299, database is CAplus.

A convenient synthesis of isothiochromen-4-one 2,2-dioxide was carried out via cyclization of o-cyanobenzyl thioacetate by a Thorpe reaction. The reactions of isothiochromen-4-one 2,2-dioxide with nitrogen-containing nucleophilic reagents have been investigated. X-rays single crystal structures of five compounds are shown.

Tetrahedron Letters published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C7H5I2NO3, Recommanded Product: 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Li, Wei published the artcileFacile synthesis of 1,2,4-trisubstituted imidazoles via aerobic copper catalyzed ligand-free [3+2] cycloaddition, Application of (E)-4-(2-Nitrovinyl)benzonitrile, the publication is Letters in Organic Chemistry (2014), 11(5), 386-392, database is CAplus.

A simple and facile approach to highly functionalized imidazoles in moderate to good yields was developed. This method involves Cu-catalyzed aerobic [3+2] cycloaddition of amidines with nitro olefins in absence of ligand. Based on observation of the intermediates, possible reaction mechanism different from the same reported approach was proposed.

Letters in Organic Chemistry published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Application of (E)-4-(2-Nitrovinyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Seck, Pierre published the artcileSynthesis of new selenophene and thiazole analogues of the tacrine series, Application of 2-Aminomalononitrile 4-methylbenzenesulfonate, the publication is ARKIVOC (Gainesville, FL, United States) (2012), 431-441, database is CAplus.

New 2-aminoselenophene-3-carbonitriles and 5-amino-1,3-thiazole-4-carbonitriles were prepared and reacted with cycloalkanones to give tetrahydroselenolo[2,3-b]quinolines, cycloalkene-fused selenolo[3,2-e]pyridines, [1,3]thiazolo[5,4-b]quinolines, thiazolo[4,5-e]pyridines, and tetrahydro-[1,3]thiazolo[5,4-b]quinolines.

ARKIVOC (Gainesville, FL, United States) published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C27H39ClN2, Application of 2-Aminomalononitrile 4-methylbenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Rafiee, E. published the artcileCobalt polyoxometalate, [CoW₁₂O₄₀]^5-, as a new reusable catalyst for addition of trimethylsilyl cyanide to carbonyl compounds, Quality Control of 13312-84-0, the publication is Bulletin of the Korean Chemical Society (2005), 26(10), 1585-1587, database is CAplus.

A series of cyanohydrin trimethylsilyl ethers have been prepared via cyanosilylation of various carbonyl compounds with trimethylsilyl cyanide. The reaction was catalyzed with potassium dodecatungstocobaltate trihydrate which was found to be a convenient and reusable catalyst.

Bulletin of the Korean Chemical Society published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Quality Control of 13312-84-0.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Feng, Huan-Xi published the artcileAn Efficient One-Pot Approach to the Construction of Chiral Nitrogen-Containing Heterocycles under Mild Conditions, Related Products of nitriles-buliding-blocks, the publication is Organic Letters (2015), 17(15), 3794-3797, database is CAplus and MEDLINE.

A new, general, and practical procedure for the highly enantioselective synthesis of functionalized nitrogen-containing heterocycles, e.g., I, has been developed. The simple cyclic hemiaminals were directly catalyzed for the first time as nucleophiles in an enamine-based asym. conjugate addition reaction. The practical approach recycles the catalyst and solvent which make it possible for large-scale and diversity-oriented chem. production

Organic Letters published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Related Products of nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Ooi, Takashi published the artcileZr(OtBu)₄ as a new promoter for the Meerwein-Ponndorf-Verley alkynylation and cyanation of aldehydes, Product Details of C8H6ClNO, the publication is Synlett (2000), 69-70, database is CAplus.

Zr(OCMe₃)₄ can serve as an effective promoter for the Meerwein-Ponndorf-Verley alkynylation of aldehydes, and it was found to be particularly attractive in the Meerwein-Ponndorf-Verley cyanation.

Synlett published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Product Details of C8H6ClNO.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts