Month: December 2022

Ishiyama, Tatsuo published the artcileA stoichiometric aromatic C-H borylation catalyzed by iridium(i)/2,2′-bipyridine complexes at room temperature, SDS of cas: 479411-95-5, the publication is Angewandte Chemie, International Edition (2002), 41(16), 3056-3058, database is CAplus and MEDLINE.

Room-temperature C-H borylation using a stoichiometric amount of arenes and bis(pinacolato)diboron (pin₂B₂) is efficiently catalyzed by iridium(I) complexes generated from [{Ir(OMe)(cod)}₂] (cod = 1,5-cyclooctadiene) and 4,4′-di-tert-butyl-2,2′-bipyridine (dtbpy) in hexane, and provides the corresponding arylboronates in excellent yields. Thus, [{Ir(OMe)(cod)}₂]/dtbpy catalyzed C-H borylation of 1,2-dichlorobenzene with pin₂B₂ in hexane at 25° for 8h gave 82% 3,4-Cl₂C₆H₃Bpin.

Angewandte Chemie, International Edition published new progress about 479411-95-5. 479411-95-5 belongs to nitriles-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Nitrile,Boronic acid and ester,Benzene,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzonitrile, and the molecular formula is C14H15BF3NO2, SDS of cas: 479411-95-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Tominaga, Masahide published the artcile24-Fold Endohedral Functionalization of a Self-Assembled M₁₂L₂₄ Coordination Nanoball, Computed Properties of 68569-14-2, the publication is Journal of the American Chemical Society (2005), 127(34), 11950-11951, database is CAplus and MEDLINE.

A ca. 5 nm-sized, roughly spherical hollow complex was assembled from 12 Pd²⁺ ions and 24 bis(4-pyridylethenyl)-substituted bent ligands. By putting a functional group at the curvature of the ligand, the 24 functional groups were precisely arrayed inward within the spherical complex. When oligo(ethylene oxide) was anchored, the void of the hollow complex was tightly filled with a pseudo poly(ethylene oxide) nanoparticle, which showed metal ion (La³⁺) absorption property.

Journal of the American Chemical Society published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C3H9ClOS, Computed Properties of 68569-14-2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Taylor, Edward C. published the artcileA new synthesis of aminomalononitrile tosylate, Synthetic Route of 5098-14-6, the publication is Synthesis (1980), 801-2, database is CAplus.

The title salt (I) was prepared from NaCH(CN)₂. Thus, 2,4,6-Me₃C₆H₂SO₂ONH₂ was added to NaCH(CN)₂ in THF, the mixture stirred under N₂ 2.5 h at 0°, the 2,4,6-Me₃C₆H₂SO₃Na formed was separated, 4-MeC₆H₄SO₃H added, and the mixture refrigerated overnight to give I.

Synthesis published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C4H4OS, Synthetic Route of 5098-14-6.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Szczesniak, Piotr published the artcileAsymmetric Synthesis of Cyclic Nitrones via Organocatalytic Michael Addition of Aldehydes to Nitroolefins and Subsequent Reductive Cyclization., HPLC of Formula: 5153-73-1, the publication is ChemistrySelect (2017), 2(9), 2670-2676, database is CAplus.

A direct approach to the synthesis of optically active five-membered cyclic nitrones I [R¹ = H, Me, OBn, etc., R² = H, Et, Ph, etc.; R¹R² = (CH₂)₄, (CH₂)₅; R³ = Ph, 2-naphthyl, 2-thienyl, etc.] was described. The presented strategy was based on organocatalytic Michael addition of aldehydes to trans-nitroalkenes to afford γ-nitroaldehydes II and subsequent reductive cyclization to form 4-substituted-3-(aryl)-3,4-dihydro-2H-pyrrole-1-oxides I. The developed methodol. was successfully applied to the asym. synthesis of Methdilazine.

ChemistrySelect published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C8H17Br, HPLC of Formula: 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Fisher, D. E. published the artcileFate of Banvel T, ioxynil, Tordon, and trifluralin in the dairy cow, Computed Properties of 3336-34-3, the publication is Journal of Dairy Science (1965), 48(12), 1711-15, database is CAplus.

The metabolic fate of 5 ppm. of 4 orally administered herbicides was determined by gas chromatography on neutron activation analysis of total I in the feces, urine, rumen contents, and milk of dairy cows. No residues of Banvel T (2-methoxy-3,5,6-trichlorobenzoic acid), ioxynil (3,5-diiodo-4-hydroxybenzonitrile), or trifluralin (α,α,α-trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine) were found in the milk. Banvel T and Tordon (4-amino-3,5,6-trichloropicolinic acid) were eliminated unchanged in the urine. No ioxynil or a possible metabolite, 3,5-diiodo-4-hydroxybenzoic acid, was found in the milk, urine, or feces by gas chromatography, but neutron activation analysis of total I indicated that substantial amounts of ioxynil and a metabolite, possibly 3-iodo-4-hydroxybenzonitrile, were present. Trifluralin completely disappeared during 24 hrs. in an artificial rumen, possibly due to nitro reduction

Journal of Dairy Science published new progress about 3336-34-3. 3336-34-3 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Phenol, name is 2,6-Dichloro-3-hydroxybenzonitrile, and the molecular formula is C7H3Cl2NO, Computed Properties of 3336-34-3.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Singh, Shivendra published the artcileRapid access of 2,3,4-trisubstituted-2,3,4,9-tetrahydrothiopyrano[2,3-b]indole derivatives via one-pot three component catalytic reaction, Synthetic Route of 5153-73-1, the publication is Tetrahedron Letters (2012), 53(45), 6087-6090, database is CAplus.

A simple, green, and efficient one-pot three component strategy for the synthesis of 2-aryl-3-nitro-4-hydroxy-2,3,4,9-tetrahydrothiopyrano[2,3-b]indoles I [R = Boc, EtO₂C; R¹ = Ph, 4-MeC₆H₄, 2-ClC₆H₄, etc.; R² = H, Me] has been achieved by the combination of N-protected-2-chloro-3-formylindoles, sodium hydrosulfide with β-nitrostyrenes R¹CH:C(R²)NO₂ at room temperature in ethanol using DABCO as a catalyst. Furthermore, high enantio- and diastereoselectives’ syntheses of title compounds have been achieved for the first time using cupreidine (5 mol %) as catalyst, providing good to excellent yields.

Tetrahedron Letters published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C10H15ClO3S, Synthetic Route of 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Frasson, Ilaria published the artcileSynthesis and photocytotoxic activity of [1,2,3]triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines, Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate, the publication is European Journal of Medicinal Chemistry (2019), 176-193, database is CAplus and MEDLINE.

[1,2,3]Triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines were synthesized with the aim to investigate their photocytotoxic activity. Upon irradiation, oxazolo-naphtapyridines induced light-dependent cell death at nanomolar/low micromolar concentrations (EC₅₀ 0.01-6.59 μM). The most photocytotoxic derivative showed very high selectivity and photocytotoxicity indexes (SI = 72-86, PTI>5000), along with a triplet excited state with exceptionally long lifetime (18.0 μs) and high molar absorptivity (29781 ± 180 M^-1cm^-1 at λ_max 315 nm). The light-induced production of ROS promptly induced an unquenchable apoptotic process selectively in tumor cells, with mitochondrial and lysosomal involvement. Altogether, these results demonstrate that the most active compound acts as a promising singlet oxygen sensitizer for biol. applications.

European Journal of Medicinal Chemistry published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Ronco, Cyril published the artcileSynthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors, Formula: C10H11N3O3S, the publication is Bioorganic & Medicinal Chemistry (2009), 17(13), 4523-4536, database is CAplus and MEDLINE.

A new series of huprines (12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolines, prepared as huperzine-tacrine hybrids) are prepared and their inhibition of recombinant human acetylcholinesterase (rh-AChE) is reported. We have synthesized two series of huprine analogs; in the first one, the benzene ring of the quinoline moiety has been replaced either by different heterocycles or by Ph groups with electron-withdrawing or electron-donating substituents. In the second series, different short linkers are introduced at the 12-positions of the huprine X and Y skeletons to evaluate the influence of modifications at the 12-position. The compounds are prepared from ethyl- or methyl-substituted bicyclo[3.3.1]non-6-en-3-one by Friedlaender reactions with o-aminocyano aromatic compounds The synthesis of two heterodimers with structures based on huprines has been also reported. Activities ranging from moderate to similar to those of huprines X and Y are obtained, with the most potent analog having a third of the activity of the parent huprines X and Y. Topol. data have been inferred from mol. docking; variation in activity with variation in the linking moieties suggest future structural modifications for activity improvement.

Bioorganic & Medicinal Chemistry published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, Formula: C10H11N3O3S.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Castro, E. A. published the artcileStructure and reactivity of arylcyanohydrins, Related Products of nitriles-buliding-blocks, the publication is Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie (1974), 29(3-4), 209-12, database is CAplus.

The relation between structure and reactivity was examined for 18 RCH(OH)CN (I, R = substituted phenyl) by CNDO/2 calculation of the stability of I (dissociation constant for I �RCHO + HCN) and of at. energy terms.

Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Related Products of nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Song, Bok Joo published the artcileA Desirable Hole-Conducting Coadsorbent for Highly Efficient Dye-Sensitized Solar Cells through an Organic Redox Cascade Strategy, Related Products of nitriles-buliding-blocks, the publication is Chemistry – A European Journal (2011), 17(40), 11115-11121, S11115/1-S11115/10, database is CAplus and MEDLINE.

This hole-conducting co-adsorbent (HC-A) has multiple functions: a light-harvesting function as a short-wavelength light absorption dye mol. to increase J_sc, a prevention effect of π-π stacking of organic dye to enhance V_oc by decreasing charge recombination, and a hole-conducting function, evidenced by EIS and transient absorption spectra for the formation of carbazole cation radical species, to enhance V_oc and J_sc. As a result, a DSSC with the HC-A had improved efficiency by a factor of 1.33, compared to a similar solar cell without the HC-A. The photovoltaic performance of this DSSC exhibited a remarkably high J_sc of 17.25 mA/cm², a V_oc of 688 mV, a FF of 74.93% and a conversion efficiency of 8.89 % at 100 mW/cm². This is the best result reported for a DSSC employing the organic dye NKX2677. The detailed kinetics for a cascade-type hole-hopping process proposed here is complicated and constitutes another topic for research.

Chemistry – A European Journal published new progress about 373389-97-0. 373389-97-0 belongs to nitriles-buliding-blocks, auxiliary class OLED Materials,Red Fluorescence Dopants, name is 4-(3,6-Dibromo-9H-carbazol-9-yl)benzonitrile, and the molecular formula is C7H6O3, Related Products of nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts