Month: December 2022

Kalugin, V. E. published the artcileThe synthesis of 3-cyano-2-(organylamino)thieno[3,2-c]isoquinoline derivatives, Quality Control of 612-13-5, the publication is Russian Chemical Bulletin (2019), 68(3), 588-596, database is CAplus.

A method for the preparation of 3-cyano-2-(organylamino)thieno[3,2-c]isoquinoline derivatives was developed. Alkylation of (2,2-dicyano-1-organylaminovinyl)thiolates with Me 2-(chloromethyl)benzoate or N-substituted 2-(chloromethyl)benzamides with the subsequent treatment of the alkylation products with potassium tert-butoxide gave 3-cyano-2-(organylamino)thieno[3,2-c]isoquinolin-5(4H)-ones. In the case of utilization of (chloromethyl)benzonitrile in this synthesis, 5-amino-3-cyano-2-organylaminothieno[3,2-c]iso-quinolines were obtained.

Russian Chemical Bulletin published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Quality Control of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kalugin, V. E. published the artcileSynthesis of 5-aminopyrido[3′,2′:4,5]thieno[3,2-c]isoquinoline derivatives from 3-cyanopyridine-2(1H)-thiones and 2-(chloromethyl)benzamide, Formula: C8H6ClN, the publication is Russian Chemical Bulletin (2018), 67(8), 1492-1499, database is CAplus.

Substituted 5-aminopyrido[3′,2′:4,5]thieno[3,2-c]isoquinolines were synthesized by condensation of substituted 3-cyanopyridine-2(1H)-thiones with 2-(chloromethyl)benzamide and subsequent treatment of the condensation products with potassium tert-butoxide. Oxidation of the condensation products to sulfoxides and sulfones followed by treatment of these compounds with potassium tert-butoxide gave substituted 5-aminopyrido[3′,2′:4,5]thieno[3,2-c]isoquinoline 11-oxides and substituted 5-aminopyrido[3′,2′:4,5]thieno[3,2-c]isoquinoline 11,11-dioxides in good yields.

Russian Chemical Bulletin published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Formula: C8H6ClN.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kalugin, V. E. published the artcileSynthesis of substituted 5-aminobenzothieno[3,2-c]isoquinolines and their sulfinyl and sulfonyl derivatives, Category: nitriles-buliding-blocks, the publication is Russian Chemical Bulletin (2015), 64(4), 878-882, database is CAplus.

A method for the preparation of substituted 5-aminobenzothieno[3,2-c]isoquinolines I, (R = H, Me, Cl), in good yields by the condensation of substituted 2-mercaptobenzonitriles with 2-(chloromethyl)benzonitrile and a subsequent treatment of the condensation products with potassium tert-butoxide was suggested. The oxidation of the condensation products to sulfoxides or sulfones and a subsequent treatment of these compounds with potassium tert-butoxide led to the preparation of substituted 5-aminobenzothieno[3,2-c]isoquinoline 11-oxides or 5-aminobenzothieno[3,2-c]isoquinoline 11,11-dioxides in good yields.

Russian Chemical Bulletin published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Category: nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kalugin, V. E. published the artcileSynthesis of derivatives of pyrido[3′,2′:4,5]furo[3,2-c]isoquinoline heterocyclic system, Computed Properties of 612-13-5, the publication is Russian Chemical Bulletin (2014), 63(2), 426-430, database is CAplus.

An approach to the synthesis of derivatives of new heterocyclic system, pyrido[3′,2′:4,5]-furo[3,2-c]isoquinoline I [R = R¹= Me; R = Ph, R¹ = 4-MeC₆H₄, 2-thienyl; R = CF₃, R¹ = Ph], was suggested. A condensation reaction of substituted 3-cyanopyridin-2(1H)-ones with Me 2-(chloromethyl)benzoate and subsequent treatment of the condensation product with potassium tert-butoxide leads to substituted pyrido[3′,2′:4,5]furo[3,2-c]-isoquinolin-5(6H)-ones. Similarly, a condensation reaction of substituted 3-cyanopyridin-2(1H)-ones with 2-(chloromethyl)benzonitrile and subsequent treatment of the condensation product with potassium tert-butoxide gives substituted 5-aminopyrido[3′,2′:4,5]furo[3,2-c]-isoquinolines II.

Russian Chemical Bulletin published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Computed Properties of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zhang, Hong-Jian published the artcileSynthesis and pharmacological evaluation of new 3,4-dihydroisoquinolin derivatives containing heterocycle as potential anticonvulsant agents, Formula: C8H6ClN, the publication is Molecules (2016), 21(12), 1635-1650, database is CAplus and MEDLINE.

Novel, fused 3,4-dihydroisoquinolines I (R¹ = H, Me, n-C₅H₁₁, etc.) and II [R² = n-C₆H₁₃ (III), n-C₇H₁₅, n-C₈H₁₇, PhCH₂, 4-ClC₆H₄CH₂] were synthesized and evaluated for their anticonvulsant activity using maximal electroshock (MES) test and pentylenetetrazole (PTZ)-induced seizure test. Among them, compound III showed significant anticonvulsant activity in MES tests with an ED₅₀ value of 63.31 mg/kg and it showed wide margins of safety with protective index (PI > 7.9). Compound III showed much higher anticonvulsant activity than that of valproate. Compound III also demonstrated potent activity against PTZ-induced seizures. A docking study of compound III in the benzodiazepine (BZD)-binding site of γ-aminobutyric acid_A (GABA_A) receptor confirmed possible binding of compound with the BZD receptors.

Molecules published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C5H7NO, Formula: C8H6ClN.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Xu, Chunfa published the artcilePalladium-Catalyzed Trifluoromethylthiolation of Aryl C-H Bonds, Computed Properties of 68569-14-2, the publication is Organic Letters (2014), 16(7), 2046-2049, database is CAplus and MEDLINE.

A method for monotrifluoromethylthiolation of arenes via palladium-catalyzed directed C-H bond activation was described. The reaction was compatible with a variety of functional groups. Initial mechanistic studies disclosed that the turnover limiting step of the catalytic cycle did not involve C-H activation.

Organic Letters published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C7H5Cl2NO, Computed Properties of 68569-14-2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Huang, R. published the artcileSynthesis and performances of extended conjugated stilbene fluorescent dye, Application In Synthesis of 612-13-5, the publication is Pigment & Resin Technology (2017), 46(4), 1-14, database is CAplus.

The purpose of this research is to explore the optical performance of extended stilbene derivative Five steps were adopted to synthesize novel 4, 4′-bis(2-cyanostyryl) stilbene, which contained three vinyl units in the skeleton (S3E). The structure of S3E was characterized by ¹H NMR and EI-MS. Its absorption and emission spectra were given as well. Compared to C.I. Fluorescent Brightener 199, which contains two vinyl units in the skeleton, S3E showed obvious bathochromic shifts in both UV-VIS and FL spectra. The maximum absorption wavelength and fluorescent wavelength were at 390 nm and 464 nm, resp., with Stoke’s shift of 74 nm. The absolute fluorescence quantum yield was 0.42. Thermogravimetric anal. revealed that the weight loss of S3E was less than 5% at 300°C. Moreover, the light resistance test showed that S3E in PVC plate can keep the good fluorescent intensity for more than 7 days exposed to xenon light. Therefore, it is believed that S3E could satisfy the requirements of coloring PVC as a fluorescent dye. S3E can be used as a candidate of fluorescent dye in the development of thermoplastics. The present work designed and synthesized a new derivative of stilbene, which could become a preferred colorant for thermoplastics.

Pigment & Resin Technology published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Application In Synthesis of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kadir, Kamaliah published the artcilePurines, pyrimidines, and imidazoles. Part 56. Some aminoimidazolecarboxamidines and derived adenines, Formula: C10H11N3O3S, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1980), 2728-31, database is CAplus.

Cyclohexylimidazole I, prepared (37%) from H₂NCH(CN)₂, CH(OEt)₃, and cyclohexylamine, gave 66% carboximidate II (R = OMe) on treatment with MeOH/HCl, which with NH₃ gave 64% carboxamidine II (R = NH₂) (III). Formylation of III gave N⁶-formyladenine IV (R = cyclohexyl), which was also prepared by formylation of 9-cyclohexyladenine. IV [R = CH₂CH(OH)CH₂OH] was similarly prepared The reaction of II (R = H) with HCO₂H/Ac₂O gave N⁶-formyladenine (IV; R = H), which was also prepared by formylation of adenine, whereas adenosine was not N-formylated under the same conditions.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, Formula: C10H11N3O3S.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

He, Jian published the artcilePd(II)-Catalyzed Enantioselective C(sp³)-H Borylation, Category: nitriles-buliding-blocks, the publication is Journal of the American Chemical Society (2017), 139(9), 3344-3347, database is CAplus and MEDLINE.

Pd(II)-catalyzed enantioselective borylation of C(sp³)-H bonds has been realized for the first time using chiral acetyl-protected aminomethyl oxazoline ligands. This reaction is compatible with carbocyclic amides containing α-tertiary as well as α-quaternary carbon centers. The chiral β-borylated amides are useful synthons for the synthesis of chiral β-hydroxylated, β-fluorinated, and β-arylated carboxylic acids.

Journal of the American Chemical Society published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C10H12F6N4O6PdS2, Category: nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Wang, Jian-Shu published the artcileAcOH-catalyzed aza-Michael addition/N-nitrosation: An efficient approach to CF₂HCH₂-containing N-nitrosoamines, Name: (E)-4-(2-Nitrovinyl)benzonitrile, the publication is Tetrahedron (2018), 74(28), 3904-3911, database is CAplus.

A simple and highly efficient protocol for the AcOH-catalyzed three-component reaction of nitroalkenes, difluoroethylamine and tert-Bu nitrite through cascade aza-Michael addition/N-nitrosation has been developed. A range of CF₂HCH₂-containing N-nitrosoamines were obtained in good to excellent yields. This approach features easily available cheap materials, without using addnl. organic solvents, simple operation under room temperature, gram scalable preparation and functionally diverse products.

Tetrahedron published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C8H7N3, Name: (E)-4-(2-Nitrovinyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts