Month: December 2022

Moeini, Nazanin published the artcileSelective oxidation of sulfides and synthesis of 5-substituted 1H-tetrazoles on Ce (III) immobilized CoFe2O4 as a magnetically separable, highly active, and reusable nanocatalyst, COA of Formula: C8H4N2, the main research area is cobalt iron oxide nanocatalyst cerium immobilized amino glycol preparation; tetrazole green preparation; nitrile sodium azide cobalt iron oxide nanocatalyst cerium immobilized; sulfoxide green preparation; sulfide oxidation cobalt iron oxide nanocatalyst cerium immobilized.

Reactions of CoFe2O4 magnetic nanoparticles supported ligands, 2-amino-2-methyl-1,3-propanediol (Amino glycol), with cerium salts provided the resp. anchored complex CoFe2O4 @Amino glycol/Ce. The nanocatalyst was characterized perfectly using thermogravimetric analyzes, FT-IR spectroscopy, SEM, energy-dispersive X-ray inductively coupled plasma optical emission spectroscopy vibrational sample magnetometry and powder X-ray diffraction. CoFe2O4 magnetic nanoparticles supported ligands with cerium salts afforded active catalysts for the synthesis of 5-substituted 1H-tetrazoles I [R = Ph, 2-ClC6H4, Bn, etc.] via reaction of nitriles and sodium azide/oxidation of sulfides RSR1 [R = Ph, n-Pr, Et, etc.; R1 = Me, Bn, Ph, etc.] using Me Ph sulfide with H2O2 as oxidant at mild reaction conditions in the green medium under optimized conditions. The ligand and metal atom identity influenced the catalytic activity of the nanocatalyst. The immobilized complexes were easily collected via an external magnetic field and further reused at least 6 times without significant loss of catalytic activity and selectivity.

Research on Chemical Intermediates published new progress about Green chemistry. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, COA of Formula: C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Aghapoor, Kioumars published the artcileCrystalline salicylic acid as an efficient catalyst for ultrafast Paal-Knorr pyrrole synthesis under microwave induction, Computed Properties of 1885-29-6, the main research area is pyrrole preparation green; primary amine hexanedione Paal Knorr cyclocondensation crystalline salicylic acid.

In this study, the viability of a wide range of crystalline aromatic and aliphatic carboxylic acids as organocatalysts has been investigated for solvent-free Paal-Knorr pyrrole synthesis under microwave activation. Among these potential catalysts, crystalline salicylic acid proved to be a remarkable catalyst because its efficiency remained high even under low microwave power irradiation or a shorter reaction time for the model reaction. The outstanding catalytic activity of salicylic acid allowed the Paal-Knorr cyclocondensation with a turnover frequency up to 1472 h-1 which is unique in the context of a metal-free homogeneous catalysis. The attractive feature of this organocatalyst is its assistance in ultrafast pyrrole synthesis with no risk of metal contamination.

Journal of Chemical Sciences (Berlin, Germany) published new progress about Green chemistry. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Shihui published the artcilePhotocatalytic C-H silylation of heteroarenes by using trialkylhydrosilanes, HPLC of Formula: 91-15-6, the main research area is photocatalytic silylation heteroarene hydrosilane green chem.

The efficient and selective C-H silylation of heteroarenes, especially the pharmaceutically relevant electron-deficient heteroarenes, represents a great challenge in organic synthesis. Herein we wish to report a distinctive visible light-promoted photocatalytic C-H silylation approach that enables the direct coupling of trialkylhydrosilanes with both electron-deficient and -rich heteroarenes as well as with cyano-substituted arenes in moderate to high yields and with good regioselectivity. The protocol features operational simplicity, mild reaction conditions, and the use of safe and readily available Na2S2O8, bis(trimethylsilyl) peroxide (BTMSPO) or iPr3SiSH as the radical initiators. Notably, the challenging bulky and inert trialkylhydrosilanes, such as (t-butyldimethyl)silane (tBuMe2SiH) and (triisopropyl)silane (iPr3SiH), work smoothly with the protocol. Moreover, despite the higher stability of tBuMe2Si silylation products, our studies revealed their great reactivity and versatility in diverse C-Si-based chem. transformations, providing an operationally simple, low-cost, and environmentally benign synthetic technol. for mol. construction and elaboration.

Chemical Science published new progress about Green chemistry. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kamal, Arsala published the artcileVisible Light-Induced Cu-Catalyzed Synthesis of Schiff’s Base of 2- Amino Benzonitrile Derivatives and Acetophenones, Quality Control of 1885-29-6, the main research area is aminobenzonitrile acetophenone copper azomethine chromophore.

An efficient, mild, and environment-friendly methodol. for the synthesis of azomethine chromophores through the reaction of 2-aminobenzonitrile derivatives and acetophenones has been developed using CuCl (10 mol %) catalyst and toluene as a solvent under visible light irradiation The reaction proceeds readily at room temperature under 20 W white LED with good to excellent yields in short reaction time. This methodol. shows significant advantages such as environmentally benign reaction conditions, sustainability, enumerating tolerance of wide range of functional groups, cost-effectiveness, high atom economy, short reaction time, and applicability for large-scale synthesis.

ChemistrySelect published new progress about Green chemistry. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bauer, R. published the artcileEnantioselective hydration of 2-arylpropionitriles by a nitrile hydratase from Agrobacterium tumefaciens strain d3, Computed Properties of 42872-30-0, the main research area is enantioselective hydration arylpropionitrile nitrile hydratase Agrobacterium.

The enantioselective nitrile hydratase from the bacterium Agrobacterium tumefaciens d3 was purified and completely separated from the amidase activity that is also present in cell extracts prepared from this strain. The nitrile hydratase had an activity optimum at pH 7.0 and a temperature optimum of 40 °C. The holoenzyme had a mol. mass of 69 kDa, the subunits a mol. mass of 27 kDa. The enzyme hydrated various 2-arylpropionitriles and other aromatic and heterocyclic nitriles. With racemic 2-phenylpropionitrile, 2-phenylbutyronitrile, 2-(4-chlorophenyl)propionitrile, 2-(4-methoxy)propionitrile or ketoprofen nitrile the corresponding (S)-amides were formed enantioselectively. The highest enantiomeric excesses (ee > 90% until about 30% of the resp. substrates were converted) were found for the amides formed from 2-phenylpropionitrile, 2-phenylbutyronitrile and ketoprofen nitrile. For the reaction of the purified nitrile hydratase, higher ee values were found than when whole cells were used in the presence of an inhibitor of the amidase activity. The enantioselectivity of the whole-cell reaction was enhanced by increasing the reaction temperature

Applied Microbiology and Biotechnology published new progress about Enzyme kinetics. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Computed Properties of 42872-30-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Rooney, C. S. published the artcileInhibitors of glycolic acid oxidase. 4-Substituted 3-hydroxy-1H-pyrrole-2,5-dione derivatives, Quality Control of 30482-87-2, the main research area is hydroxypyrroledione preparation glycolate oxidase inhibition; urinary oxalate calculi hydroxypyrroledione; QSAR hydroxypyrroledione glycolate oxidase inhibition.

The title compounds I (R = aryl, aryloxy, heterocycle, etc.; R1 = H, Me, or Ph) and related ones were prepared and evaluated as orally absorbable inhibitors of glycolic acid oxidase (GAO) [9028-71-1] and to examine their effect on oxalate production in animals. Inhibitors of GAO are of interest as potentially useful drugs for treatment of Ca oxalate renal lithiasis and the primary hyperoxalurias. Rat liver perfusion with 3 of the most potent I have shown effective inhibition of the conversion of glycolate to oxalate in this organ. 4-(4′-Bromo[1,1′-biphenyl]-4-yl)-3-hydroxy-1H-pyrrole-2,5-dione (I; R = C6H4-4-(4-BrC6H4); R1 = H) [77529-42-1] administered orally to ethylene glycol treated rats showed reduction in oxalate excretion in urine. QSAR are discussed.

Journal of Medicinal Chemistry published new progress about Enzyme kinetics. 30482-87-2 belongs to class nitriles-buliding-blocks, name is 2,6-Dichloro-4-methoxybenzonitrile, and the molecular formula is C8H5Cl2NO, Quality Control of 30482-87-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Banstola, Bijay published the artcileSublimation Electrification of Organic Compounds, Application In Synthesis of 91-15-6, the main research area is sublimation electrification organic compound elec current.

The electrification of crystalline deposits of organic compounds under high vacuum was measured and quantified. A group of compounds that produce multiply charged ions by matrix-assisted ionization were deposited on a metal plate, and the current was amplified and recorded; the total charge was obtained by integration of the current. Signals of several hundred picoamperes were obtained within 10 s of the application of high vacuum and persisted for several minutes as the compounds sublimed. The magnitude and sign of the charge were matrix dependent and were affected by the presence of organic or mineral acid in the crystalline deposit, as well as by the application of an elec. field. The observations are interpreted as surface electrification caused by the emission of small charged matrix particles during sublimation, with ionic charge carriers comprising protons and hydroxide ions.

Journal of the American Society for Mass Spectrometry published new progress about Electric charge. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application In Synthesis of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chinnusamy, Tamilselvi published the artcileRecyclable MeOPEG-clicked TEMPO catalyst for one-pot aerobic double dehydrogenation of alcohols to nitriles, HPLC of Formula: 100-70-9, the main research area is immobilized MeOPEG clicked TEMPO catalyst preparation; nitrile green preparation; alc aerobic double dehydrogenation immobilized MeOPEG clicked TEMPO catalyst.

In this study, TEMPO was efficiently grafted on MeOPEG support by copper-catalyzed (3+2) cycloaddition reaction. The newly immobilized MeOPEG-clicked TEMPO catalyst was characterized by NMR, IR, and MALDI-TOF. Subsequently, it was used for one-pot aerobic double dehydrogenation of alcs. to nitriles using aqueous ammonia as the nitrogen source and O2 (1 atm) as the terminal oxidant. The catalytic efficiency was also reported with various benzyl, alkyl and heteroaromatic alcs. The reactivity of this catalyst was comparable with that of unmodified TEMPO. Furthermore, the new MeOPEG-clicked TEMPO catalyst could be easily recovered by precipitation and recycled up to five runs.

Catalysis Communications published new progress about Dehydrogenation. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wu, Yuling published the artcileSynthesis and properties of hyperbranched polymers for polymer light emitting devices with sunlight-style white emission, Quality Control of 100-70-9, the main research area is fluorene carbazole iridium phosphor hyperbranched polymer light emitting device; Suzuki coupling polycondensation white light emission electroluminescent device.

A new series of hyperbranched polymers consisting of fluorene-alt-carbazole as the branches and the 3D-structured spiro[3.3]heptane-2,6-dispirofluorene (SDF) as the core were designed and synthesized by one-pot Suzuki coupling polycondensation. A phosphor group with broad full width at half maximum (FWHM) bis(1-phenyl-isoquinoline)(acetylacetonato)iridium(III)(Ir(Brpiq)2acac, 0.08 mol%) as the red-light emitting unit and bis(2-(4-bromophenyl)-1-[6-(9-carbazolyl)hexyl]-imidazole)(2-(5-(4-fluorinated phenyl)-1,3,4-triazole)pyridine)iridium(III)((CzhBrPI)2Ir(fpptz)) as the green-light emitting unit were introduced into the backbones to obtain sunlight-style white-light emission by adjusting the feeding ratios of (CzhBrPI)2Ir(fpptz) (0.08 to 0.32 mol%). The results indicate the LUMO levels of polymers were reduced and the electron injection was improved because of excellent electron-transporting ability of the triazole unit in the green group. The hyperbranched structures can effectively suppress the polymers’ chain distortion and aggregation, and promote the incomplete Forster resonance energy transfer efficiency from fluorene-alt-carbazole segments to Ir complex units. As a result, the devices with hyperbranched polymer light-emitting layers realize white light emission, and the optimized device also exhibits good electroluminescent (EL) performance with CIE coordinates at (0.32, 0.31), a maximum luminance of 9054 cd m-2, a maximum current efficiency of 3.59 cd A-1 and a maximum CRI of 91.

RSC Advances published new progress about Current density. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mukherjee, Jit published the artcileUnderstanding the Site-Selective Electrocatalytic Co-Reduction Mechanism for Green Urea Synthesis Using Copper Phthalocyanine Nanotubes, HPLC of Formula: 91-15-6, the main research area is copper phthalocyanine nanotube electroccatalytic coredn green urea preparation.

Green synthesis of urea under ambient conditions by electrochem. co-reduction of N2 and CO2 gases using effective electrocatalyst essentially pushes the conventional two steps (N2 + H2 = NH3 and NH3 + CO2 = CO(NH2)2) industrial process at high temperature and high pressure, to the brink. The single step electrochem. green urea synthesis process has hit a roadblock due to the lack of efficient and economically viable electrocatalyst with multiple active sites for dual reduction of N2 and CO2 gas mols. to urea. Herein, copper phthalocyanine nanotubes (CuPc NTs) having multiple active sites (such as metal center, Pyrrolic-N3, Pyrrolic-N2, and Pyridinic-N1) as an efficient electrocatalyst which exhibits urea yield of 143.47μg h-1 mg-1cat and faradaic efficiency of 12.99% at -0.6 V vs. reversible hydrogen electrode by co-reduction of N2 and CO2 are reported. Theor. calculation suggests that Pyridinic-N1 and Cu centers are responsible to form CN bonds for urea by co-reduction of N2 to NN* and CO2 to *CO, resp. This study provides the new mechanistic insight about the successful electro-reduction of dual gases (N2 and CO2) in a single mol. as well as rational design of efficient noble metal-free electrocatalyst for the synthesis of green urea.

Advanced Functional Materials published new progress about Current density. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts