Month: December 2022

Xu, Lili published the artcileProcess improvement on synthesis of 1,4-bis(o-cyanostyryl) benzene, Name: 2-(Chloromethyl)benzonitrile, the publication is Yingyong Huagong (2010), 39(3), 456-458, 462, database is CAplus.

1,4-Dimethylbenzene was chlorinated by dry Cl₂, then the mixed chloride products was hydrolyzed to terephthalaldehyde by hexamethylenetetramine. The purity of the product was 99.5% and the yield was 78.4%. Di-Et o-cyanobenzyl phosphonate was synthesized by the esterification reaction of tri-Et phosphatidate and o-cyanobenzyl chloride dissolved in dimethylbenzene, the yield was 86.5%. 1,4-Bis(o-cyanostyryl) -benzene was synthesized from di-Et o-cyanobenzyl phosphonate and terephthalaldehyde. The purity of the product is 99.5% (HPLC) and the yield is 84.1%.

Yingyong Huagong published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C22H38O2, Name: 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Wang, Yanping published the artcileAn efficient cyanosilylation of aldehydes with trimethylsilyl cyanide catalysed by MgI₂ etherate, COA of Formula: C8H6ClNO, the publication is Journal of Chemical Research (2012), 36(10), 566-567, database is CAplus.

A convenient procedure for the synthesis of cyanohydrins by the addition of Me₃SiCN to aromatic aldehydes, heteroaromatic aldehydes, aliphatic aldehydes and unsaturated aldehydes catalyzed by MgI₂.(OEt₂)_n in good to excellent yields was described.

Journal of Chemical Research published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, COA of Formula: C8H6ClNO.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kang, Dongwei published the artcileSynthesis and preliminary antiviral activities of piperidine-substituted purines against HIV and influenza A/H1N1 infections, Product Details of C8H6ClN, the publication is Chemical Biology & Drug Design (2015), 86(4), 568-577, database is CAplus and MEDLINE.

We have developed a series of N²-(1-(substituted-aryl)piperidin-4-yl)-N⁶-mesityl-9H-purine-2,6-diamine derivatives as potent antiviral agents. Preliminary biol. evaluation indicated that nearly half of them possessed remarkable HIV inhibitory potencies in cellular assays. In particular, FZJ13 appeared to be the most notable one, which displayed anti-HIV-1 activity compared to 3TC. Moreover, an unexpected finding was that FZJ05 displayed significant potency against influenza A/H1N1 (strain A/PR/8/34) in Madin-Darby canine kidney cells with EC₅₀ values much lower than those of ribavirin, amantadine, and rimantadine. The results suggest that these novel purine derivatives have the potential to be further developed as new therapeutic agents against HIV-1 or influenza virus.

Chemical Biology & Drug Design published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Product Details of C8H6ClN.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Jeng, Huey-Jiuan published the artcileFormation of pyrrole derivatives from heteroatom-substituted acetonitriles, Synthetic Route of 5098-14-6, the publication is Journal of the Chinese Chemical Society (Taipei) (1994), 41(6), 803-11, database is CAplus.

Aminomalononitrile reacted with conjugated carbonyl compounds to give 3H-pyrrolines. Treatment of 2-chloro-2-phenylthioacetonitrile with alkenes in the presence of potassium t-butoxide afforded 1-phenylthiocyclopropanecarbonitriles, which reacted with nucleophiles in 1,2-, 1,4- or 1,6-addition modes. The 1,2-adducts (cyclopropylimines) rearranged in situ to give substituted pyrroles.

Journal of the Chinese Chemical Society (Taipei) published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, Synthetic Route of 5098-14-6.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Chen, Weiqiang published the artcileThe Cyclohexa-2,5-dienyl Group as a Placeholder for Hydrogen: Organocatalytic Michael Addition of an Acetaldehyde Surrogate, SDS of cas: 5153-73-1, the publication is Chemistry – A European Journal (2020), 26(66), 15126-15129, database is CAplus and MEDLINE.

An aldehyde with a cyclohexa-2,5-dienyl group in the α-position is introduced as a storable surrogate of highly reactive acetaldehyde. The cyclohexa-2,5-dienyl unit is compatible with an enantioselective Michael addition to nitroalkenes promoted by a Hayashi-Jorgensen catalyst and can be removed by a boron Lewis acid mediated C-C bond cleavage. The robust two-step sequence does not require a large excess of the aldehyde component that is typically needed when directly using acetaldehyde.

Chemistry – A European Journal published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, SDS of cas: 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Bizzarri, Bruno Mattia published the artcileAminomalononitrile inspired prebiotic chemistry as a novel multicomponent tool for the synthesis of imidazole and purine derivatives with anti-influenza A virus activity, SDS of cas: 5098-14-6, the publication is RSC Advances (2021), 11(48), 30020-30029, database is CAplus and MEDLINE.

Amino imidazole carbonitrile derivatives decorated with α-amino acid side-chains have been synthesized by a multicomponent microwave assisted reaction inspired by the prebiotic chem. of aminomalononitrile as a tool for generating high chem. diversity. These compounds were used as annulation synthons for the preparation of 8,9-disubstituted-6,9-dihydro-1H-purin-6-ones by reaction with formic acid as a simple C-1 donor reagent. The novel heterocycles were characterized by significant activity against influenza A virus, amino imidazole carbonitrile derivatives showing the highest activity. Thus, the chem. complexity generated by prebiotic chem. furnished a general tool for the identification of novel antiviral agents.

RSC Advances published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, SDS of cas: 5098-14-6.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Bray, Katharine L. published the artcileHalide redistribution in Pd-catalyzed 1,6-diene cycloisomerization, Synthetic Route of 68569-14-2, the publication is Chemical Communications (Cambridge) (2001), 187-188, database is CAplus.

[(MeCN)₃PdCl]⁺, generated in situ, reversibly disproportionates to give [(MeCN)₂PdCl₂] and [(MeCN)₄Pd]²⁺. The neutral species is a reactive and highly regioselective catalyst for 1,6-diene cycloisomerization.

Chemical Communications (Cambridge) published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C10H12F6N4O6PdS2, Synthetic Route of 68569-14-2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Toh, Rou Jun published the artcileDeposition of Aminomalononitrile-Based Films: Kinetics, Chemistry, and Morphology, HPLC of Formula: 5098-14-6, the publication is Langmuir (2019), 35(30), 9896-9903, database is CAplus and MEDLINE.

In the last few years, the development of versatile coating chemistries has become a hot topic in surface science after the discovery that catecholamines can lead to conformal coatings upon oxidation from aqueous solutions Recently, it was found that aminomalononitrile (AMN), a mol. implicated in the appearance of life on earth, is an excellent prototype of novel material-independent surface functionalizing agents leading to conformal and biocompatible coatings in a simple and direct chem. process from aqueous solutions So far, very little insight has been gained regarding the mechanisms underlying coating deposition. In this paper, we show that the chem. evolution of AMN film deposition under slightly basic conditions is different in solution and on silica. Thereon, the coating proceeds via a nucleation process followed by further deposition of islands which evolve to produce nitrogen-rich superhydrophilic fibrillar structures. Addnl., we show that AMN-based material can form films at the air-solution interface from unshaken solutions These results open new vistas into the chem. of HCN-derived species of potential relevance in materials science.

Langmuir published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C17H18N2O6, HPLC of Formula: 5098-14-6.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Izquierdo, Joseba published the artcileEnantioselective Synthesis of 5,5-Disubstituted Hydantoins by Bronsted Base/H-Bond Catalyst Assisted Michael Reactions of a Design Template, Safety of (E)-4-(2-Nitrovinyl)benzonitrile, the publication is Chemistry – A European Journal (2018), 24(28), 7217-7227, database is CAplus and MEDLINE.

A new method for the enantioselective synthesis of 5,5-disubstituted (quaternary) hydantoins, e.g., I was developed on the basis of an organocatalytic Michael reaction approach involving the use of 2-benzylthio-3,5-dihydroimidazol-4-ones as key hydantoin surrogates. The method is general with respect to the substitution pattern at the hydantoin N¹ (alkyl, aryl, acyl), N³ (aryl), and C⁵ (linear/branched alkyl, aryl) positions and affords essentially single diastereomeric products with enantioselectivities higher than 95 % ee in most cases. Among the bifunctional Bronsted base/H-bond catalysts examined, a known squaramide-tertiary amine catalyst II and a newly prepared squaramide-tertiary amine catalyst III provide the highest selectivity so far with either nitroolefins or vinyl ketones as the acceptor components. Kinetic measurements support a first-order rate dependence on both reaction partners, the donor template and the Michael acceptor, whereas competitive ¹H NMR spectroscopy experiments reveal the high ability of the template for catalyst binding.

Chemistry – A European Journal published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Safety of (E)-4-(2-Nitrovinyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Diosdado, Saioa published the artcileCatalytic Enantioselective Synthesis of Tertiary Thiols From 5H-Thiazol-4-ones and Nitroolefins: Bifunctional Ureidopeptide-Based Bronsted Base Catalysis, Computed Properties of 5153-73-1, the publication is Angewandte Chemie, International Edition (2013), 52(45), 11846-11851, database is CAplus and MEDLINE.

The synthesis of the target compounds was achieved using urea-peptide analogs as catalysts (Bronsted acids). A reaction of amino acids (L-valine, 3-methyl-L-valine) with (8α,9S)-6′-methoxycinchonan-9-amine (epiquinine, cinchona alkaloid derivative) provided the above-mentioned urea-peptide analogs. These catalysts were applied in a Michael reaction of thiazolone derivatives with (nitro)alkenes. A reaction of 2-mercaptobutanoic acid, 2-(mercapto)octanoic acid, α-(mercapto)benzenepropanoic acid with nitriles provided 4-thiazolol derivatives (4-thiazolone derivatives). The title compounds thus formed included a thiazolone nitroalkane derivative (I) and related substances, quinoline derivatives, naphthalene derivatives, etc.

Angewandte Chemie, International Edition published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Computed Properties of 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts