Month: December 2022

Bartlett, Robert T. published the artcileSynthesis and pharmacological evaluation of a series of analogs of 1-methylisoguanosine, Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate, the publication is Journal of Medicinal Chemistry (1981), 24(8), 947-54, database is CAplus and MEDLINE.

Analogs of 1-methylisoguanosine (I, R = Me, R¹ = H, R² = OH) were evaluated as muscle relaxants, antiinflammatory agents, allergy inhibitors, and for cardiovascular activity. Cyclizing imidazole nucleoside II with RNCO (R = Et, Bu, octyl, Ph) and deprotecting gave I (R = Et, Bu, octyl, Ph; R¹ = H, R² = OH). Bromination of I (R = Me, R¹ = H, R² = OH) with Br₂-H₂O gave I (R = Me, R¹ = Br, R² = OH) which reacted with N₂H₄ to give I (R = Me, R¹ = NHNH₂, R² = OH). This was cleaved with Raney Ni to give I (R = Me, R¹ = NH₂, R² = OH). Deamination of 1-methylguanosine with NaNO₂ in aqueous AcOH gave 1-methylxanthosine. Iodination of I (R = Me, R¹ = H, R² = OH) with Me(PhO)₃P⁺I^– gave I (R = Me, R¹ = H, R² = iodo) which was cyclized to III or deiodinated to I (R = Me, R¹ = R² = H). The phosphate ester I (R = Me, R¹ = H, R² = OPO₃^2-) was prepared as well as cyclic phosphate IV. C-Nucleoside V was prepared from Me β-D-ribofuranosyl-1-carboximidate. Cyclizing the 9-(2-hydroxyethoxy)methyl analog of II with MeNCO gave acyclic analog VI. Similarly prepared was the β-D-arabinofuranosyl analog of I (R = Me, R¹ = H, R² = OH).

Journal of Medicinal Chemistry published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Pearson, David M. published the artcileOxidatively Resistant Ligands for Palladium-Catalyzed Aerobic Alcohol Oxidation, Recommanded Product: Tetrakis(acetonitrile)palladium(II) Ditriflate, the publication is Organometallics (2011), 30(6), 1445-1453, database is CAplus.

[(Neocuproine)Pd(OAc)]₂[OTf]₂ (1) catalyzes the aerobic oxidation of 2-heptanol at room temperature, but competitive ligand oxidation leads to low catalyst lifetimes. In an effort to mitigate the oxidative degradation of the ligand, a variety of Pd complexes ligated by fluorinated phenanthrolines (bis-2,9-(trifluoromethyl)-1,10-phenanthroline (btfm-phen), 4-methyl-2-(trifluoromethyl)-1,10-phenanthroline (tfmm-phen), and 2-(o-difluorophenyl)-1,10-phenanthroline (odfp-phen)) were prepared and tested. Active catalyst precursors were generated by in situ conproportionation of (N-N)Pd(OAc)₂ and [(N-N)Pd(NCCH₃)₂[OTf]₂]. Pd complexes derived from tfmm-phen catalyzed the aerobic oxidation of 2-heptanol at room temperature with up to 22 turnovers, nearly double that of 1.

Organometallics published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C10H12F6N4O6PdS2, Recommanded Product: Tetrakis(acetonitrile)palladium(II) Ditriflate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zuck, Donald A. published the artcileStabilization of vitamin B₁₂. II. α-Hydroxy nitriles, Recommanded Product: 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, the publication is Journal of Pharmaceutical Sciences (1963), 63-6, database is CAplus.

α-Hydroxy nitriles and esters of mandelonitrile were effective stabilizers of I except under conditions of prolonged exposure to ultraviolet light when decomposition was more rapid than in the controls.

Journal of Pharmaceutical Sciences published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C10H11NO4, Recommanded Product: 2-(2-Chlorophenyl)-2-hydroxyacetonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Hutchinson, Daniel John published the artcileSupramolecular self-assembly of heterobimetallic complexes: a new N,P-based, selective heteroditopic ligand, SDS of cas: 68569-14-2, the publication is Dalton Transactions (2018), 47(4), 1053-1061, database is CAplus and MEDLINE.

Pyrimidine-hydrazone and phosphole architectures were combined to create a new heteroditopic ligand capable of forming heterobimetallic Zn^II/Pd^II, Pb^II/Pd^II and Cu^II/Pd^II complexes in high yielding stepwise or one pot reactions. The catalytic activity of these complexes in Heck coupling and Miyaura borylation reactions was studied.

Dalton Transactions published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C10H12F6N4O6PdS2, SDS of cas: 68569-14-2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Liu, Bei-Bei published the artcileAqueous Reaction of Alcohols, Organohalides, and Odorless Sodium Thiosulfate under Transition-Metal-Free Conditions: Synthesis of Unsymmetrical Aryl Sulfides via Dual C-S Bond Formation, Synthetic Route of 612-13-5, the publication is Journal of Organic Chemistry (2017), 82(19), 10174-10180, database is CAplus and MEDLINE.

A transition-metal-free process for the synthesis of unsym. aryl sulfides via dual C-S bond formation by a one-pot three-component reaction of alcs., organohalides, and odorless sodium thiosulfate in water was developed. In addition, the aryl sulfides could also be prepared by the reaction of the corresponding alcs. and Bunte salts under the identical conditions. This protocol provides a green and efficient manner for the construction of various unsym. aryl sulfides.

Journal of Organic Chemistry published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Synthetic Route of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Sathish, Manda published the artcileIron-Mediated One-Pot Synthesis of 3,5-Diarylpyridines from β-Nitrostyrenes, Quality Control of 5153-73-1, the publication is Journal of Organic Chemistry (2016), 81(5), 2159-2165, database is CAplus and MEDLINE.

An operationally simple and mild one-pot protocol for the synthesis of a variety of 3,5-diarylpyridines from β-nitrostyrenes was achieved by using elemental iron. This reaction proceeds via reduction of the nitro group, resulting in in situ imine formation followed by trimol. condensation with concomitant debenzylative aromatization. By employing this method, a series of sym. and unsym. 3,5-diarylpyridines were synthesized with good to excellent yields. In addition, this method was also utilized for the synthesis of Sch-21418 (I), an anti-inflammatory agent on gram scale.

Journal of Organic Chemistry published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Quality Control of 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Huang, Zijun published the artcileRegioselectivity inversion tuned by iron(III) salts in palladium-catalyzed carbonylations, Recommanded Product: Tetrakis(acetonitrile)palladium(II) Ditriflate, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(32), 3967-3970, database is CAplus and MEDLINE.

By using cheap and abundant iron(III) salts, the hydroxycarbonylations of both aromatic and aliphatic alkenes were significantly enhanced in both reactivity and selectivity (iso/n or n/iso up to >99 : 1). Moreover, Pd-catalyzed carbonylation selectivity can be switched from branched to linear by using different Fe(III) salts. In addition, similar results were obtained for the carbonylation of secondary alcs.

Chemical Communications (Cambridge, United Kingdom) published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C10H12F6N4O6PdS2, Recommanded Product: Tetrakis(acetonitrile)palladium(II) Ditriflate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Liu, Liu published the artcileSynthesis and WORM memory performance of polycarbazole derivatives with different electron acceptors in the side chain, COA of Formula: C19H10Br2N2, the publication is Gongneng Gaofenzi Xuebao (2016), 29(2), 163-171, 181, database is CAplus.

Three soluble D-A type polycarbazole derivatives with different electron acceptors in the side chain, including poly[(9-(2-hexyldecyl)-9H-carbazole)-(9-(4-nitrophenyl)-9H-carbazole)] (PCz-NO₂), poly[(9-(2-hexyldecyl)-9H-carbazole)-(4-(9H-carbazole-9-yl)benzaldehyde)] (PCz-CHO), and poly[(9-(2-hexyldecyl)-9H-carbazole)-(4-(9H-carbazole-9-yl)benzonitrile)] (PCz-CN), were synthesized through the Suzuki coupling reaction. These polymers-based electronic devices with a configuration of Al (200 nm)/polymer (90 nm)/Indium-Tin Oxide (ITO) had representative bistable elec. switching behavior and non-volatile write-once read-many-times (WORM) memory performance. When the optical bandgap of conjugated polymer was increased (2.26 Ev (PCz-NO₂)→2.79 eV(PCz-CHO)→3.20 eV(PCz-CN)), the threshold voltage of the corresponding electronic device gradually increased (-1.70 V→-1.81 V→-1.89 V), whereas the ON/OFF current ratio was changed from 6.63 × 10⁴ for PCz-NO₂ to 4.08 × 10⁴ for PCz-CHO and to 5. 68 × 10³ for PCz-CN. Among these three derivatives, PCz-CN exhibited the biggest turn-on voltage and the lowest ON/OFF current ratio.

Gongneng Gaofenzi Xuebao published new progress about 373389-97-0. 373389-97-0 belongs to nitriles-buliding-blocks, auxiliary class OLED Materials,Red Fluorescence Dopants, name is 4-(3,6-Dibromo-9H-carbazol-9-yl)benzonitrile, and the molecular formula is C19H10Br2N2, COA of Formula: C19H10Br2N2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Song, Yan-ru published the artcileHPLC determination of 2-cyanobenzyl chloride, Application In Synthesis of 612-13-5, the publication is Yinran Zhuji (2007), 24(3), 45-46, database is CAplus.

Cyanobenzyl chloride content was determined by HPLC with SHIMPACK CLC ODS column (5 μm, 150 mm × 6.0 mm), UV detector (detection wave length 230 nm) and a mobile phase of MeOH and H₂O (50:50 V/V, adjusted to pH 3.0 with H₃PO₄). The linear range for 2-cyanobenzyl chloride determination was 0.15-0.80 mg/mL with γ of 0.999 9 (n = 6) and average recovery of 99.8%. The method was exact and simple, and could be used for controlling the 2-cyanobenzyl chloride quality.

Yinran Zhuji published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C6H3ClFNO2, Application In Synthesis of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Bai, Xueqian published the artcileSynthesis, antimicrobial activities, and molecular docking studies of dihydrotriazine derivatives bearing a quinoline moiety, Computed Properties of 612-13-5, the publication is Chemistry & Biodiversity (2019), 16(6), n/a, database is CAplus and MEDLINE.

In this article, three series of dihydrotriazine derivatives bearing a quinoline moiety (5a, 5b, 8a-8c, and 9a-9m) have been designed, synthesized, and evaluated as antibacterial agents. Compounds 8a-8c were found to be the most potent of all of the compounds tested with an MIC value of 1 μg/mL against several Gram-pos. (S. aureus 4220 and MRSA CCARM 3506) and Gram-neg. (E. coli 1924) strains of bacteria. In addition, 3-[4-amino-6-(phenethylamino)-2,5-dihydro-1,3,5-triazin-2-yl)-6-[(3-chlorobenzyl)oxy]quinolin-2-ol (8a) showed potent inhibitory activity (MIC=2 μg/mL) against Pseudomonas aeruginosa 2742, indicating that its antibacterial spectrum is similar to those of the pos. controls gatifloxacin and moxifloxacin. Structure-activity relationships (SAR) analyses and docking studies implicated the dihydrotriazine group in increasing the antimicrobial potency of the quinoline compounds In vitro enzyme study implied that compound 8a also displayed DHFR inhibition.

Chemistry & Biodiversity published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Computed Properties of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts