Month: December 2022

Rocker, Johannes published the artcileAlternatives to Iridium: A Polyaza[7]helicene as a Strongly Reductive Visible Light Photoredox Catalyst, Name: Picolinonitrile, the main research area is poly azahelicene photo redox catalyst.

The use of a readily accessible polyazahelicene as a strongly reducing metal-free alternative to the commonly used precious metal based photo redox catalysts is demonstrated. An improved two-step synthesis of the catalyst is described, and its photophys. properties with respect to its use as a photo redox catalyst are evaluated. Its activity under visible light irradiation is proven by application in two double radical light-driven multi-component reactions. The azahelicene gave comparable results to an iridium-based catalyst originally used for the same transformations.

ACS Organic & Inorganic Au published new progress about Absorption. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Name: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ishikawa, Yuta published the artcileRed-light-activatable ruthenium phthalocyanine catalysts, Name: Phthalonitrile, the main research area is ruthenium phthalocyanine red light activatable catalyst.

Phthalocyanine ruthenium complexes were identified as red-light activatable catalysts for trifluoromethylation reactions. The red-light mediated chlorotrifluoromethylation of alkenes could proceed without any sacrificial reducing reagents. This reaction exhibited good compatibility with a blue-light-absorbing substrate, while under irradation with blue light, i.e., under traditional photoreaction conditions, this substrate decomposed completely.

Chemical Communications (Cambridge, United Kingdom) published new progress about Absorption. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Name: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Wenzhi published the artcileMethoxypolyethylene Glycol-Substituted Zinc Phthalocyanines for Multiple Tumor-Selective Fluorescence Imaging and Photodynamic Therapy, Computed Properties of 91-15-6, the main research area is photodynamic therapy fluorescence imaging pharmacokinetics.

Highly tumor-tissue-selective drugs are a prerequisite for accurate diagnosis and efficient photodynamic therapy (PDT) of tumors, but the currently used fluorescent dyes and photosensitizers generally lack the ability for high accumulation and precise localization in tumor tissues. Here we report that monomethoxy polyethylene glycol (MPEG)-modified zinc phthalocyanine (ZnPc) can be selectively accumulated in multiple tumor tissues, and that the selectivity is controlled by the chain length of MPEG. MPEG-monosubstituted ZnPcs with different chain lengths were synthesized, among which the shorter chain (mw < 2k)-modified ZnPc did not show tumor tissue selectivity, while MPEG2k-5k-substituted ZnPc could be rapidly and selectively accumulated in H22 tumor tissues in mice after i.v. injection. Especially, MPEG4k-Pc showed the best tumor tissue selectivity with a tumor/liver (T/L) ratio of 1.7-2.2 in HepG2, MDA-MB231, AGS, and HT-29 tumor-bearing mice. It also exhibited potent photodynamic therapy effects after one PDT treatment, and tumor growth was significantly inhibited in H22-bearing mice with an inhibition rate over 98% and no obvious toxicity. Consequently, MPEG-modified ZnPc could serve as a potential platform for selective fluorescence imaging and photodynamic therapy of multiple tumors. Biomacromolecules published new progress about Absorption. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Computed Properties of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bhatia, Harsh published the artcileAsymmetric-donor (D2D2)-acceptor (A) conjugates for simultaneously accessing intrinsic blue-RTP and blue-TADF, Formula: C8H4N2, the main research area is donor acceptor photoluminescent room temperature phosphorescence.

The development of new photoluminescent (PL) materials with simultaneous room-temperature phosphorescence (RTP) and thermally activated delayed fluorescence (TADF) features is highly desirable for bio-imaging, security applications and sensors due to the involvement of both singlet and longer-lived triplet states. Here, we report two carbazolyl-phenoxy-phthalonitrile conjugates (CPPN, CPPNF). Spectroscopic studies combining two daughter compounds (PPN, PPNF) in polar and nonpolar hosts confirmed efficient blue-RTP from the higher-energy triplet state (TPPN) due to the phenoxy-phthalonitrile (PPN) part, and blue-TADF via reverse intersystem crossing from the low-lying triplet state (TCzPN) of the carbazolyl-phthalonitrile (CzPN) part to the singlet (S1) state of the same CzPN part, utilizing the TPPN state that acts as an intermediate for spin-vibronic coupling. Such PL characteristics are observed due to the energetic proximity of 3LEPPN, 1CTCzPN and 3CTCzPN. In the hydrogen-bonded matrix and crystals, we found faint persistent green-RTP characteristics of the PPNF due to supramol. interactions and aggregation of the mol. This study could pave the way to understanding the involvement of different excited states associated with TADF and RTP processes of asym.-donor-acceptor systems.

Materials Advances published new progress about Absorption. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Formula: C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Olgun, Ugursoy published the artcileNano-gold-based synthesis, characterization and band gap energies of gold(III)-2(3)-tetrakis(allyloxy)-substituted phthalocyanine and gold(III)-phthalocyanine dyes, Quality Control of 91-15-6, the main research area is gold tetrakis allyloxy phthalocyanine band gap oxidation.

In this study, we have attempted to synthesize Au (III)-phthalocyanine (Au-Pc) and Au (III)-2 (3)-tetrakis (allyloxy) phthalocyanine (Au-AoPc) by using phthalonitrile (Pn), 3 allyloxy-substituted phthalonitrile (Ao-Pn) and gold nanoparticles (AuNPs) as the starting materials. The N,N′-dimethyl amino ethanol (DMAE)-stabilized AuNPs were prepared from the HAuCl4 solution The purple color AuNPs were obtained by the reduction of HAuCl4 solution by the addition of DMAE and adjusting pH 6-7 at room temperature Then, the blue color Au-Pc and the green color Au-AoPc dye materials were synthesized at 120 °C temperature by the reactions of the AuNPs with Pn and AoPn. The obtained AuNPs, Au-Pc and Au-AoPc complexes were characterized using optical microscopy, transmission electron microscopy (TEM), UV-Vis absorption, FT-IR and electrospray ionization-mass spectrometry. The TEM anal. results showed that the sizes of AuNPs were mostly 30-40 nm and distributed within the range of 10-100 nm. By using the Tauc method, the optical band gap energies (Eg) were calculated as 1.66 eV for the Q-band and 3.12 eV for the B-band of the Au-Pc, and as 1.79 eV for the Q-band and 3.32 eV for the B-band of the Au-AoPc. The DMAE-stabilized AuNPs, the Au-Pc and the soluble Au-AoPc dyes with low band gap energy can be utilized for various technologies in electronics, imaging, sensors and solar cells.

Journal of Materials Science: Materials in Electronics published new progress about Absorption. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Quality Control of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Han published the artcileDesign, synthesis and biological activities of piperidine-spirooxadiazole derivatives as α7 nicotinic receptor antagonists, Formula: C6H4N2, the main research area is benzyl aryl oxa triazaspiro decene preparation SAR; aryl oxa triazaspiro decene preparation mol docking SAR; Antagonists; Piperidine-spirooxadiazole derivatives; SAR; α7 nAChR.

7 Nicotinic acetylcholine receptors (nAChRs) expressed in the nervous and immune systems was suggested to play important roles in the control of inflammation. However, the lack of antagonist tools specifically inhibiting α7 nAChR impedes the validation of the channel as therapeutic target. To discover a selective α7 antagonist, a pharmacophore-based virtual screening and identified a piperidine-spirooxadiazole derivative T761-0184 that acts as a α7 antagonist. A series of novel piperidine-spirooxadiazole derivatives were subsequently synthesized and evaluated using two-electrode voltage clamp (TEVC) assay in Xenopus oocytes. Lead compounds from two series inhibited α7 with their IC50 values ranging from 3.3μM to 13.7μM. Compound 3-(4-Bromophenyl)-8-methyl-1-oxa-2,4,8-triazaspiro[4.5]dec-2-ene exhibited α7 selectivity over other α4β2 and α3β4 nAChR subtypes. The anal. of structure-activity relationship (SAR) provides valuable insights for further development of selective α7 nAChR antagonists.

European Journal of Medicinal Chemistry published new progress about Cyclization. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zatsikha, Yuriy V. published the artcileEnvironmentally Benign Route for Scalable Preparation of 1-Imino-3-thioisoindolines-The Key Building Blocks for the Synthesis of Dithio- and Diamino-β-isoindigo Derivatives, COA of Formula: C8H4N2, the main research area is imino thioisoindoline synthesis; dithio diamino beta isoindigo derivative synthesis.

A one-step, gram-scale protocol for the preparation of 1-imino-3-thioisoindolines and a novel one-pot two-step methodol. of the synthesis of dithio- or diamino-β-isoindigo derivatives starting from phthalonitriles and sodium hydrosulfide in an aprotic dipolar solvent have been developed. It was demonstrated that the electronic properties of the substituent(s) in the phthalonitrile core play a critical role in β-isoindigo synthesis resulting either in the selective formation of dithio- or diamino-β-isoindigo chromophores. The N-acylated 1-imino-3-thioisoindolines can be used for the direct, easily scalable, and chromatog.-free procedure for the preparation of a new class of N,N’-diacylamino-β-isoindigoid compounds Properties of the monomeric as well as J-aggregated forms of dithio- and diamino-β-isoindigo were probed by the absorption and fluorescence spectroscopies. It was demonstrated that the tetracyano-diamino-β-isoindigo 3f can form a J-aggregate that absorbs at 793 nm and fluoresces at 824 nm. This aggregate is stable in N,N-dimethylformamide solution; however, it slowly dissociates in THF or under sonication conditions. D. functional theory (DFT) and time-dependent DFT (TDDFT) calculations were employed to elucidate the electronic structures, spectroscopic properties, and aggregation of new dithio- and diamino-β-isoindigo derivatives

Journal of Organic Chemistry published new progress about Cyclization. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, COA of Formula: C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chan, Joseph Y. M. published the artcile[3 + 1] Mixed Cyclization: A Synthetic Route to Prepare Low-Symmetry Phthalocyanines, HPLC of Formula: 91-15-6, the main research area is zinc phthalocyanine nanoparticle preparation; base promoted cyclization trisphthalonitrile metal template.

A novel synthetic strategy for low-symmetry phthalocyanines was developed, which involves the base-promoted cyclization of a preconnected trisphthalonitrile and a free phthalonitrile in the presence of a metal template. By using this [3 + 1] mixed cyclization approach, a series of zinc(II) phthalocyanine derivatives were synthesized in up to 12% yields, including a very rare ABCD-type phthalocyanine and an amphiphilic ABAC-type analog that can self-assemble in aqueous media, forming stable spherical nanoparticles.

Journal of Organic Chemistry published new progress about Cyclization. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Chunyan published the artcileA practical base mediated synthesis of 1,2,4-triazoles enabled by a deamination annulation strategy, Recommanded Product: Picolinonitrile, the main research area is trisubstituted triazole preparation; nitrile hydrazine deamination annulation base mediated.

A rapid and efficient base mediated synthesis of 1,3,5-trisubstituted 1,2,4-triazoles I [R = i-Pr, Ph, 1-naphthyl, etc.; R1 = n-Bu, Ph, 2-furyl, etc.] was developed using the annulation of nitriles with hydrazines, which could be expanded to a wide range of triazoles in good to excellent yields. Ammonia gas was liberated during the reaction, and halo and hetero functional groups as well as free hydroxyl and amino groups are tolerated in this transformation. A variety of alkyl and aryl-substituted nitriles could be functionalized with aromatic and aliphatic hydrazines employing this procedure. This finding provided a practical and useful strategy for the synthesis of various 15N-labeled 1,2,4-triazole derivatives, and two types of mGlu5 receptor pharmaceuticals could be easily assembled in a one-pot manner.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cyclization. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts