A facile and environmentally benign polyethylene glycol 600-mediated method for the synthesis of densely functionalized 2-aminothiophene derivatives under ultrasonication was written by Akbarzadeh, Ali;Dekamin, Mohammad G.. And the article was included in Green Chemistry Letters and Reviews in 2017.Related Products of 70291-62-2 This article mentions the following:
A green and efficient protocol for the synthesis of densely functionalized 2-aminothiophene derivatives is described by the one-pot three-component Gewald reaction of enolizable carbonyl compounds, malononitrile (or Et cyanoacetate) and elemental sulfur in polyethylene glycol 600, as an eco-friendly reaction medium. The reaction was carried out without using any basic compounds under ultrasonic irradiation and PEG-600 can be recovered and reused at least five times without significant loss of its activity. The merits of this protocol are mild reaction conditions, good yields, short reaction time, simple work-up procedure and recyclability of the reaction medium as well as avoiding the use of any basic catalyst at ambient temperature In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Related Products of 70291-62-2).
2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Related Products of 70291-62-2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts