Synthesis and in vitro acetylcholinesterase and butrylcholinesterase inhibitory activity of tacrine (cognex) derivatives was written by Gregor, Vlad E.;Emmerling, Mark R.;Lee, Chitase;Moore, Catherine J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1992.Product Details of 53312-77-9 This article mentions the following:
Chlorosubstituted derivatives of tacrine, I (X = H, 5-, 6-, 7-, 8-Cl, n = 0), and of 1,4-methylenetacrine, I (n = 1), and their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities are described. Thus, 2-aminobenzonitriles II (X = H, 3-, 4-, 5-, 6-Cl) cyclized with cyclohexanone or norcamphor to give I (n = 0, 1), resp. The most potent analogs are 6-chlorotacrine I (X = 6-Cl, n = 0) in AChE and 7-chlorotacrine I (X = 7-Cl, n = 0) in BChE inhibition. In the experiment, the researchers used many compounds, for example, 2-Amino-3-chlorobenzonitrile (cas: 53312-77-9Product Details of 53312-77-9).
2-Amino-3-chlorobenzonitrile (cas: 53312-77-9) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Product Details of 53312-77-9
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts