Substituted benzocarbocycles by palladium-catalyzed cascade reactions featuring a C(sp3)-H activation step was written by Hitce, Julien;Baudoin, Olivier. And the article was included in Advanced Synthesis & Catalysis in 2007.Electric Literature of C8H5Br2N This article mentions the following:
Valuable 4- and 5-membered benzocarbocycles were synthesized via selective Pd-catalyzed cascade reactions which combined C(sp3)-H activation, Heck cyclization, Heck arylation or olefin hydrogenation. In all cases, all mechanistically independent steps were catalyzed by a single multi-functional catalyst, e.g. Pd(OAc)2/(5-F-2-MeC6H3)3P. One product, (E)-1-ethyl-2-[(3,4,5-trimethoxyphenyl)methylene]benzocyclobutane-1-carbonitrile, showed promising antimicrotubule activity. In the experiment, the researchers used many compounds, for example, 2-(2,6-Dibromophenyl)acetonitrile (cas: 67197-53-9Electric Literature of C8H5Br2N).
2-(2,6-Dibromophenyl)acetonitrile (cas: 67197-53-9) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Electric Literature of C8H5Br2N
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts