Iridium-Monodentate Phosphoramidite-Catalyzed Asymmetric Hydrogenation of Substituted Benzophenone N-H Imines was written by Hou, Guohua;Tao, Ran;Sun, Yongkui;Zhang, Xumu;Gosselin, Francis. And the article was included in Journal of the American Chemical Society in 2010.Reference of 62584-32-1 This article mentions the following:
Homogeneous asym. hydrogenation of unprotected benzophenone N-H imines using Ir-(S)-N-benzyl-N-methyl-MonoPhos as a catalyst provides chiral diarylmethylamines in 80-96% yield with enantioselectivities up to 98% ee (18 examples) for substituted substrates. In the experiment, the researchers used many compounds, for example, 2-Chloro-3-(trifluoromethyl)benzonitrile (cas: 62584-32-1Reference of 62584-32-1).
2-Chloro-3-(trifluoromethyl)benzonitrile (cas: 62584-32-1) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Reference of 62584-32-1
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts