Oxidative fluorination of arenes was written by Meurs, Jan H. H.;Sopher, David W.;Eilenberg, Wolf. And the article was included in Angewandte Chemie in 1989.COA of Formula: C7H4FNO This article mentions the following:
Phenol and benzene derivatives underwent selective oxidative fluorination by HF-base mixture Thus, treatment of phenol with PbO2, HF, and pyridine afforded 50% 4,4-difluoro-2,5-cyclohexadienone. The latter was formed in 25% yield by anodic oxidation of phenol in the presence HF-Et3N. In the experiment, the researchers used many compounds, for example, 2-Fluoro-5-hydroxybenzenecarbonitrile (cas: 104798-53-0COA of Formula: C7H4FNO).
2-Fluoro-5-hydroxybenzenecarbonitrile (cas: 104798-53-0) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.COA of Formula: C7H4FNO
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts