Iron- and copper-based bifunctional catalysts for the base- and solvent-free C-N coupling of amines and aryl/benzyl chlorides under aerobic conditions was written by Sharma, Charu;Srivastava, Avinash K.;Sharma, Deepak;Joshi, Raj K.. And the article was included in New Journal of Chemistry in 2022.Recommanded Product: 4-(Benzylamino)benzonitrile This article mentions the following:
The iron chalcogenide carbonyl cluster Fe3Se2(CO)9 and Cu(OAc)2 were found to be outstanding bimetallic catalysts for the C-N coupling reaction of amines and aryl chlorides. The reaction proceeded under base- and solvent-free conditions at 100°C to produce excellent transformations of N-arylated products in just 4 h. The method worked equally well for all the possible variants of amines, including aliphatic, aromatic and benzylic amine. The present C-N coupling method was highly economical, strongly feasible and showed excellent competence with electron-withdrawing and base-sensitive functionalities. Moreover, it was the first report in which a zero-valent iron complex was explored for C-N coupling reaction. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Recommanded Product: 4-(Benzylamino)benzonitrile).
4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Recommanded Product: 4-(Benzylamino)benzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts