Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes was written by Shi, Yongjia;Gao, Qian;Xu, Senmiao. And the article was included in Journal of the American Chemical Society in 2019.COA of Formula: C8H5BrFN This article mentions the following:
The authors herein report an Ir-catalyzed enantioselective C(sp3)-H borylation of cyclopropanecarboxamides using a chiral bidentate boryl ligand for the 1st time. A variety of substrates with α-quaternary C centers could be compatible in this reaction to provide β-borylated products with good to excellent enantioselectivities. Also the borylated products can be used as versatile precursors engaging in stereospecific transformations of C-B bonds, including the synthesis of a bioactive compound Levomilnacipran. In the experiment, the researchers used many compounds, for example, 2-(3-Bromo-4-fluorophenyl)acetonitrile (cas: 501420-63-9COA of Formula: C8H5BrFN).
2-(3-Bromo-4-fluorophenyl)acetonitrile (cas: 501420-63-9) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.COA of Formula: C8H5BrFN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts