One-Pot Synthesis of Quinazolines via Elemental Sulfur-Mediated Oxidative Condensation of Nitriles and 2-(Aminomethyl)anilines was written by Tan, Yuxing;Jiang, Wujiu;Ni, Penghui;Fu, Yang;Ding, Qiuping. And the article was included in Advanced Synthesis & Catalysis in 2022.Recommanded Product: 2-Amino-3-chlorobenzonitrile This article mentions the following:
A strategy for the synthesis of quinazolines I [R = H, 6-Me, 8-Br, etc.; Ar = Ph, 4-MeC6H4, 2-ClC6H4, etc.] via elemental sulfur-mediated oxidative condensation of nitriles and 2-(aminomethyl)anilines was developed. The reaction was carried out under metal-/solvent-free conditions, tolerated a wide range of functional groups to provide the corresponding products in 56%-91% yield, and was performed on a gram-scale. The UV/Vis absorption and fluorescence spectra of several product derivatives were measured to study their photophys. properties. In the experiment, the researchers used many compounds, for example, 2-Amino-3-chlorobenzonitrile (cas: 53312-77-9Recommanded Product: 2-Amino-3-chlorobenzonitrile).
2-Amino-3-chlorobenzonitrile (cas: 53312-77-9) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Recommanded Product: 2-Amino-3-chlorobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts