β-Amino alcohols as ligands for asymmetric transfer hydrogenation of ketones in water was written by Wu, Xiaofeng;Li, Xiaohong;McConville, Matthew;Saidi, Ourida;Xiao, Jianliang. And the article was included in Journal of Molecular Catalysis A: Chemical in 2006.HPLC of Formula: 101219-69-6 This article mentions the following:
Chiral β-amino alcs. were used as ligands for ruthenium, rhodium and iridium-catalyzed asym. transfer hydrogenation of acetophenone derivatives in water with formate as reductant. The catalysts were shown to be capable of asym. transfer hydrogenation of ketones in water, but their activities and enantioselectivity varied with the ligands used and with solution pH values, with higher pH favoring higher rates and better enantioselectivity. In the experiment, the researchers used many compounds, for example, (R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6HPLC of Formula: 101219-69-6).
(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.HPLC of Formula: 101219-69-6
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts