Meisenheimer-type adducts from thiophene derivatives. Part 6. A kinetic and thermodynamic study of substituent effects on the formation of some non-gem adducts was written by Arnone, Caterina;Consiglio, Giovanni;Spinelli, Domenico;Dell’Erba, Carlo;Sancassan, Fernando;Terrier, Francois. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1989.Application of 42137-24-6 This article mentions the following:
The rate and equilibrium constants for the formation of the Meisenheimer-type adducts I and II from 4-nitro-2-X- or 2-nitro-4-X-thiophenes and sodium methoxide have been measured at 25° in methanol or methanol-DMSO mixtures The observed stability and reactivity patterns have been interpreted in the light of the hyper-ortho relation in the thiophene ring and the special ability of the nitro group to stabilize effectively the adducts from a para-like position also. In the experiment, the researchers used many compounds, for example, 4-Nitrothiophene-2-carbonitrile (cas: 42137-24-6Application of 42137-24-6).
4-Nitrothiophene-2-carbonitrile (cas: 42137-24-6) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Application of 42137-24-6
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts