Highly Enantioselective Hydrosilylation of Ketones Catalyzed by a Chiral Oxazaborolidinium Ion was written by Kang, Byung Chul;Shin, Sung Ho;Yun, Jaesook;Ryu, Do Hyun. And the article was included in Organic Letters in 2017.Application In Synthesis of (R)-4-(1-Hydroxyethyl)benzonitrile This article mentions the following:
A highly enantioselective hydrosilylation of ketones was developed for the synthesis of a variety of chiral secondary alcs. In the presence of a chiral oxazaborolidinium ion (COBI) catalyst, the reaction proceeded with good yields (up to 99%) with excellent enantioselectivities (up to 99% ee). In the experiment, the researchers used many compounds, for example, (R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6Application In Synthesis of (R)-4-(1-Hydroxyethyl)benzonitrile).
(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Application In Synthesis of (R)-4-(1-Hydroxyethyl)benzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts