Structure-selectivity relationship in the chemoselective hydrogenation of unsaturated nitriles was written by Kukula, Pavel;Koprivova, Klara. And the article was included in Journal of Catalysis in 2005.Safety of 2-Cyclohexylacetonitrile This article mentions the following:
Several unsaturated nitriles of various structures (cinnamonitrile, cyclohex-1-enyl-acetonitrile, acrylonitrile, 3,3-dimethyl-acrylonitrile, geranylnitrile, and 2- and 3-pentenenitrile) with different substituents at the double bond were hydrogenated over Cr-doped Raney cobalt and nickel and over their undoped equivalent The substitution and the position of the double bond relative to the nitrile group are crucial in determining the chemoselectivity for the unsaturated amine. The double bond is not hydrogenated when it is sterically hindered or if it is too far from the nitrile group (cyclohex-1-enyl-acetonitrile, double bond at C-6 in geranylnitrile). In conjugated systems, such as acrylonitrile or 2-pentenylnitrile, the activated double bond is hydrogenated before the nitrile. An addnl. Me substituent at the double bond enhances the selectivity for unsaturated amines and, thus, 3,3-dimethyl-acrylonitrile and geranylnitrile were hydrogenated with selectivity up to 40%. The highest selectivities for unsaturated amines (up to 90%) were reached during the hydrogenation of nonconjugated systems, such as cyclohex-1-enyl-acetonitrile and 3-pentenylnitrile. In the experiment, the researchers used many compounds, for example, 2-Cyclohexylacetonitrile (cas: 4435-14-7Safety of 2-Cyclohexylacetonitrile).
2-Cyclohexylacetonitrile (cas: 4435-14-7) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Safety of 2-Cyclohexylacetonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts