Pyrrolo[1,2-a][1,4]benzodiazepine: A novel class of non-azole anti-dermatophyte anti-fungal agents was written by Meerpoel, Lieven;Van Gestel, Jef;Van Gerven, Frans;Woestenborghs, Filip;Marichal, Patrick;Sipido, Vic;Terence, Gilkerson;Nash, Roger;Corens, David;Richards, Ray D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.HPLC of Formula: 53312-77-9 This article mentions the following:
Broad screening revealed compound I to be a novel anti-fungal agent with high specificity towards dermatophytes. The anti-fungal structure-activity relationship of this novel class of 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepines is described together with its mode of action that appeared to be the inhibition of squalene epoxidase. Preliminary in vivo results of the most active compounds are also reported. In the experiment, the researchers used many compounds, for example, 2-Amino-3-chlorobenzonitrile (cas: 53312-77-9HPLC of Formula: 53312-77-9).
2-Amino-3-chlorobenzonitrile (cas: 53312-77-9) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.HPLC of Formula: 53312-77-9
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts