Asymmetric transfer hydrogenation of ketones catalyzed by rhenium complexes with chiral ferrocenylphosphane ligands was written by Mejia, Esteban;Aardoom, Raphael;Togni, Antonio. And the article was included in European Journal of Inorganic Chemistry in 2012.Electric Literature of C9H9NO This article mentions the following:
A series of new rhenium complexes containing chiral ferrocenyldiphosphine ligands, I (R = Ph, Cy; R1 = Cy, 1-adamantyl, 3,5-(CF3)2C6H3, 3,5-Me2C6H3) of the Josiphos family, starting from com. available rhenium sources. These new ReV oxido and nitrido complexes, several of which have been characterized by x-ray crystallog., are air- and moisture-stable and are active catalysts in the asym. transfer hydrogenation of ketones using 2-propanol as the hydrogen source in the presence of substoichiometric amounts of triethylamine (TEA). The reaction proceeds cleanly with good to excellent yields (50-99 %) but with moderate enantioselectivity (up to 58 % ee). A mechanism not involving hydridic species is proposed. In the experiment, the researchers used many compounds, for example, (R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6Electric Literature of C9H9NO).
(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Electric Literature of C9H9NO
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts