Synthesis of cis- and trans-4-cyanocyclohexanol was written by Praefcke, Klaus;Schmidt, Dietmar. And the article was included in Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie in 1980.Application of 24056-34-6 This article mentions the following:
The title 4-cyanocyclohexanols, whose stereochem. was determined by NMR spectroscopy, were prepared for the first time by the reaction of 4-hydroxycyclohexanone with Me3COK and p-MeC6H4SO3CH2NC to give a cis-trans mixture of the title compounds, which was separated via column chromatog. of their benzoates followed by hydrolysis. In the experiment, the researchers used many compounds, for example, 4-Hydroxycyclohexanecarbonitrile (cas: 24056-34-6Application of 24056-34-6).
4-Hydroxycyclohexanecarbonitrile (cas: 24056-34-6) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Application of 24056-34-6
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts