A new synthesis of aryl substituted quinazolin-4(1H)-ones was written by Roth, Gary A.;Tai, Jimmy J.. And the article was included in Journal of Heterocyclic Chemistry in 1996.Product Details of 53312-77-9 This article mentions the following:
Treatment of a variety of substituted 2-aminobenzonitriles I (R1 = H, 3-F, R2 = 3-Me, 5-NO2, 5-OMe, 3-F, 3-Cl, 5-Cl, 6-Cl) with formic acid under strong acid catalysis provides the corresponding quinazolin-4(1H)-ones II in good yield. A potential reaction pathway is described. In the experiment, the researchers used many compounds, for example, 2-Amino-3-chlorobenzonitrile (cas: 53312-77-9Product Details of 53312-77-9).
2-Amino-3-chlorobenzonitrile (cas: 53312-77-9) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Product Details of 53312-77-9
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts