Heterocyclic Meisenheimer complexes: kinetic and equilibrium data for methoxide ion attack on various disubstituted 2,4-Y,Z-thiophenes and -selenophenes in methanol was written by Terrier, Francois;Chatrousse, Alain-Pierre;Paulmier, Claude. And the article was included in Journal of Organic Chemistry in 1979.Category: nitriles-buliding-blocks This article mentions the following:
The stabilities of I (R, R1 = NO2, NO2; CN, NO2; NO2, CN; X = Se, S) decreased in the stated order of R, R1 and of X, but different trends were found in kinetic studies. II (R = CN; R1 = NO2; X = Se, S) reacted differently with MeO– than the other II. An ortho-like NO2 group may affect nucleophilic substitution more than a para-like NO2 group. In the experiment, the researchers used many compounds, for example, 4-Nitrothiophene-2-carbonitrile (cas: 42137-24-6Category: nitriles-buliding-blocks).
4-Nitrothiophene-2-carbonitrile (cas: 42137-24-6) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts