Base-promoted N-alkylation using formamides as the N-sources in neat water was written by Chen, Wen-Xin;Zhang, Cai-Yun;Shao, Li-Xiong. And the article was included in Tetrahedron in 2014.Related Products of 37812-51-4 This article mentions the following:
An efficient catalyst-free, alternative method for the C-N bond formation reaction of alkyl electrophiles using formamides as the N-sources was achieved under mild conditions. The reaction possesses the advantages of a broad range of substrates scope and wide functional group tolerance. It should also be noted that this process was performed using the environmentally benign water as the sole solvent, and high yield can also be achieved in ten-gram scale. In the experiment, the researchers used many compounds, for example, 4-(Morpholinomethyl)benzonitrile (cas: 37812-51-4Related Products of 37812-51-4).
4-(Morpholinomethyl)benzonitrile (cas: 37812-51-4) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Related Products of 37812-51-4
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts