Dell’Erba, Carlo et al. published their research in Journal of the Chemical Society in 1989 | CAS: 42137-24-6

4-Nitrothiophene-2-carbonitrile (cas: 42137-24-6) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Synthetic Route of C5H2N2O2S

A carbon-13 NMR study of 5-cyano-, 5-methoxycarbonyl-, 5-carbamoyl-, and 5-acetyl-3-nitro-2-X-thiophenes: substituent effects and their relation to the charge distribution in corresponding 2,2-dimethoxy Meisenheimer adducts was written by Dell’Erba, Carlo;Sancassan, Fernando;Novi, Marino;Spinelli, Domenico;Consiglio, Giovanni;Arnone, Caterina;Ferroni, Fiammetta. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1989.Synthetic Route of C5H2N2O2S This article mentions the following:

A 13C NMR study in (CD3)2SO has been carried out on 5-cyano- (I), 5-methoxycarbonyl- (II), 5-carbamoyl- (III), and 5-acetyl-3-nitro-2-X-thiophenes (IV) in order to investigate the 2-X-substituent effect on the C(α) chem. shifts of the different 5-probes. The results obtained show that, unlike the case of the acetyl group, the α-carbon chem. shifts of the cyano, methoxycarbonyl, and carbamoyl groups are not appreciably affected by through-conjugation with the 2-X-substituents, π-polarization being the more important outcome of the substituent effect on the probe group. The anal. of both the C(5) and C(α) chem.-shift variations in I–IV by a gradual modification of the electron-releasing power of the substituents reveals a trend which has been interpreted as a useful indicator of the electronic effects in play on the distribution of the π-electron densities in the corresponding Meisenheimer adducts V (R = CN, CO2Me, CONH, Ac). In the experiment, the researchers used many compounds, for example, 4-Nitrothiophene-2-carbonitrile (cas: 42137-24-6Synthetic Route of C5H2N2O2S).

4-Nitrothiophene-2-carbonitrile (cas: 42137-24-6) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Synthetic Route of C5H2N2O2S

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts