Substituent effect on the acetolysis of neophyl p-bromobenzenesulfonates was written by Fujio, Mizue;Funatsu, Kimito;Shibata, Koji;Yoshinaga, Hironori;Maeda, Yasuyuki;Goto, Mutsuo;Mishima, Masaaki;Tsuno, Yuho. And the article was included in Memoirs of the Faculty of Science, Kyushu University, Series C: Chemistry in 1984.Safety of 2-(4-Methoxyphenyl)-2-methylpropanenitrile This article mentions the following:
Substituent effects on acetolysis kinetics of several RC6H4CMe2CH2OBs (Bs = brosylate; R = p-MeO, p-MeS, m-Me, etc.), as well as of some analogous disubstituted derivatives, were determined An r value (a measure of resonance demand) of 0.56 in the LArSR equation indicated that the mechanism involves a rate-determining aryl-assisted transition state, which cascades down to the tertiary carbonium ion without staying as a bridged intermediate. Thus, the substituent effect maybe viewed as the effect on the aryl-assisted ionization step. The application of the Brown ρσ+ equation is criticized. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenyl)-2-methylpropanenitrile (cas: 5351-07-5Safety of 2-(4-Methoxyphenyl)-2-methylpropanenitrile).
2-(4-Methoxyphenyl)-2-methylpropanenitrile (cas: 5351-07-5) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Safety of 2-(4-Methoxyphenyl)-2-methylpropanenitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts