Anil Synthesis in the Design of Push-Pull Systems. Synthesis of 2- and 4-(4-Styrylphenyl)-substituted Diphenylpyrimidines was written by Harutyunyan, A. A.;Panosyan, H. A.;Safaryan, M. S.;Gukasyan, G. T.;Danagulyan, G. G.. And the article was included in Russian Journal of Organic Chemistry in 2020.Product Details of 5203-15-6 This article mentions the following:
The potential of anil synthesis for the preparation of 2,4,6-triaryl-substituted pyrimidines I (R = H, OMe, i-Pr; R1 = H; RR1 = -OCH2O-) and II (R2 = H, isobutoxy) with an extended chain of delocalized π-bonds was studied. The reaction of (E)-3-phenyl-1-arylprop-2-en-1-ones 4-R3 C6H4C(O)CH=CHC(O)C6H5 (R3 = H, Me) with benzamidine hydrochlorides 4-R2C6H4C(NH2)=NH.HCl in ethanol in the presence of KOH gave pyrimidines III. The synthesized pyrimidines III were reacted with (E)-N-(phenyl- or 2-chlorophenyl)-1-arylmethanimines 4-R-5-R1C6H3CH=N(2-R4C6H4) (R4 = H, 2-Cl) in DMF in the presence of a KOH/LiH mixture to obtain (E)-4,6-diphenyl-2-(4-styrylphenyl)pyrimidines I and (E)-2,6-diphenyl-4-(4-styrylphenyl)pyrimidines II. In the experiment, the researchers used many compounds, for example, 4-iso-Butoxybenzonitrile (cas: 5203-15-6Product Details of 5203-15-6).
4-iso-Butoxybenzonitrile (cas: 5203-15-6) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Product Details of 5203-15-6
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts