Amination of Alcohols Catalyzed by Copper-Aluminum Hydrotalcite: A Green Synthesis of Amines was written by Likhar, Pravin R.;Arundhathi, Racha;Kantam, Mannepalli Lakshmi;Prathima, Parvathaneni Sai. And the article was included in European Journal of Organic Chemistry in 2009.Safety of 4-(Benzylamino)benzonitrile This article mentions the following:
Copper-aluminum hydrotalcite (CuAl-HT)/K2CO3 has been employed in the activation of various benzyl alcs. with benzylamines to afford the corresponding amines in good to high yields. Experimentation showed that the reaction takes place through sequential transformations: the oxidation of alcs. into carbonyl compounds, imine formation between amines and carbonyl compounds, and then reduction of imines to amines, heterogeneously catalyzed by non-noble Cu-Al HT catalyst in a one-pot and straightforward fashion. The process was further extended to amination of alcs. with anilines which are often resistant to alkylation reactions when substituted with strong electron-withdrawing groups. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Safety of 4-(Benzylamino)benzonitrile).
4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Safety of 4-(Benzylamino)benzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts