Ligand-Promoted Non-Directed C-H Cyanation of Arenes was written by Liu, Luo-Yan;Yeung, Kap-Sun;Yu, Jin-Quan. And the article was included in Chemistry – A European Journal in 2019.Quality Control of 3-(tert-Butyl)benzonitrile This article mentions the following:
The first example of a 2-pyridone accelerated non-directed C-H cyanation with an arene as the limiting reagent was reported. This protocol was compatible with a broad scope of arenes, including advanced intermediates, drug mols. and natural products. A kinetic isotope experiment (kH/kD=4.40) indicated that the C-H bond cleavage is the rate-limiting step. Also, the reaction is readily scalable, further showcasing the synthetic utility of this method. In the experiment, the researchers used many compounds, for example, 3-(tert-Butyl)benzonitrile (cas: 154532-34-0Quality Control of 3-(tert-Butyl)benzonitrile).
3-(tert-Butyl)benzonitrile (cas: 154532-34-0) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Quality Control of 3-(tert-Butyl)benzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts