Synthesis of strontium ranelate was written by Sun, Ningning;Wang, Decai;Jiang, Jian. And the article was included in Huagong Shikan in 2007.Application of 58168-20-0 This article mentions the following:
The improved synthetic method for strontium ranclate was realized from citric acid by decarboxylation, esterification, cyclization, alkylation, hydrolyzation and then salt formation. The total yield reached 58.6%. The improved technol. condition is moderate, the operating is simple, and adapts industrialization production In the experiment, the researchers used many compounds, for example, Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0Application of 58168-20-0).
Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Application of 58168-20-0
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts