Polarography of substituted nitrothiophenes was written by Tirouflet, Jean;Chane, Jean Paul. And the article was included in Compt. rend. in 1956.HPLC of Formula: 42137-24-6 This article mentions the following:
A direct correlation between the half-wave potentials of corresponding benzene and thiophene derivatives has been reported previously (C.A. 50, 10562e). The half-wave-potential increments due to substituent X in the 5-position in 2- and 3-nitrothiophene are determined and found to be equal within exptl. error with the corresponding increments in nitrobenzene, X-substituted in the para- and meta-position, resp. (X is: CH3, I, CH(OCOCH3)2, CH:NOH, C(CH3):NOH, CO2H, COCH3, CN, CHO, CO2C2H5). The increments are pH independent between 2 and 12. The half-wave increments in the benzene series had been shown (Tirouflet, C.A. 50, 8343g) to be connected by the Hammett equation; hence the equation also holds for the thiophene series and the σ values are of the same order of magnitude. Some anal. applications of the increments are described. In the experiment, the researchers used many compounds, for example, 4-Nitrothiophene-2-carbonitrile (cas: 42137-24-6HPLC of Formula: 42137-24-6).
4-Nitrothiophene-2-carbonitrile (cas: 42137-24-6) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.HPLC of Formula: 42137-24-6
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts