Synthesis and structural elucidation of novel 2,4-disubstituted 1,3-oxazole analogues for pharmacological properties was written by Venugopala, Katharigatta N.. And the article was included in Asian Journal of Chemistry in 2018.Reference of 60979-25-1 This article mentions the following:
Novel 2,4-disubstituted 1,3-oxazole analogs (3a-i) were designed and synthesized between 1-[3,5-bis(trifluoromethyl)-phenyl]-2-bromoethan-1-one and substituted amides by microwave assisted method. 2,4-Disubstituted 1,3-oxazole analogs obtained were at excellent yields and purity of the compound was ascertained by HPLC. The chem. structure of these compounds was elucidated by spectrometric (FTIR, NMR and LCMS) and elemental anal. Microwave method influenced the better yield and reduction in reaction time when compared to conventional reflux method. In the experiment, the researchers used many compounds, for example, 3-Amino-4-methoxybenzonitrile (cas: 60979-25-1Reference of 60979-25-1).
3-Amino-4-methoxybenzonitrile (cas: 60979-25-1) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Reference of 60979-25-1
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts