Synthesis of 5-[bis(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiopheneacetic acid strontium salt (strontium ranelate) was written by Wang, Qiang;Pan, Hongjuan;Yuan, Zhedong. And the article was included in Zhongguo Yiyao Gongye Zazhi in 2007.Related Products of 58168-20-0 This article mentions the following:
A method for the synthesis of the title compound [i.e., distrontium ranelate, 5-[bis(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiopheneacetic acid strontium salt] is reported here. Strontium ranelate (a bone formation stimulant) was synthesized from di-Et 1,3-acetonedicarboxylate [i.e., 3-oxopentanedioic acid 1,5-di-Et ester ] by a cyclization with sulfur and malononitrile, condensation with Et chloroacetate to give 5-[N,N-bis(ethoxycarbonylmethyl)amino]-4-cyano-3-ethoxycarbonylmethyl-2-thiophenecarboxylic acid Et ester, which was subjected to alk. hydrolysis with strontium hydroxide. The overall yield was 34%. In the experiment, the researchers used many compounds, for example, Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0Related Products of 58168-20-0).
Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Related Products of 58168-20-0
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts