Simple, efficient catalyst system for the palladium-catalyzed amination of aryl chlorides, bromides, and triflates was written by Wolfe, John P.;Tomori, Hiroshi;Sadighi, Joseph P.;Yin, Jingjun;Buchwald, Stephen L.. And the article was included in Journal of Organic Chemistry in 2000.Electric Literature of C14H12N2 This article mentions the following:
Palladium complexes supported by (2-PhC6H4)P(CMe3)2 (I) or (2-PhC6H4)PCy2 (II; Cy = cyclohexyl) are efficient catalysts for the catalytic amination of a wide variety of aryl halides and triflates. Use of ligand I allows for the room-temperature catalytic amination of many aryl chloride, bromide, and triflate substrates, while ligand II is effective for the amination of functionalized substrates or reactions of acyclic secondary amines. The catalysts perform well for a large number of different substrate combinations at 80-110°, including chloropyridines and functionalized aryl halides and triflates using 0.5-1.0 mol% Pd; some reactions proceed efficiently at low catalyst levels (0.05 mol% Pd). These ligands are effective for almost all substrate combinations that have been previously reported with various other ligands, and they represent the most generally effective catalyst system reported to date. I and II are air-stable, crystalline solids that are com. available. Their effectiveness is due to a combination of steric and electronic properties that promote oxidative addition, Pd-N bond formation, and reductive elimination. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Electric Literature of C14H12N2).
4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Electric Literature of C14H12N2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts