Brodfuehrer, Paul R. et al. published their research in Organic Process Research & Development in 1997 | CAS: 101219-69-6

(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.HPLC of Formula: 101219-69-6

Asymmetric Synthesis of the Antiarrhythmia Agent d-Sotalol was written by Brodfuehrer, Paul R.;Smith, Patrick;Dillon, John L.;Vemishetti, Purushotham. And the article was included in Organic Process Research & Development in 1997.HPLC of Formula: 101219-69-6 This article mentions the following:

A chiral synthesis of d-Sotalol (I) was developed starting from com. available 4′-(chloroacetyl)methanesulfonanilide. Key step was the asym. reduction of the ketone by BH3-THF in the presence of a chiral borane. In the experiment, the researchers used many compounds, for example, (R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6HPLC of Formula: 101219-69-6).

(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.HPLC of Formula: 101219-69-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts